I have had 11 metho injections so far and GI is doing another colonoscopy at 4 month mark (would have been 3 months if not for Christmas) so he must think we should know by then if it is working. I have inflammation at a stricture site which may be a different situation than some of the other replies. I take 5 mg. folic acid daily and my husband gives me the injections. I went from 6-7 bowel movements a day to 1-2 after first injection. I have no diarrhea and no nausea. The real test will be to see if a scope shows inflammation. If so, next step may be a resection.