melatonin and Crohn's?

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New Member

Date Joined Nov 2008
Total Posts : 17
   Posted 11/1/2008 11:12 PM (GMT -6)   
just wondering if you guys think melatonin is ok to take if I have crohn's and am being treated with Humira?

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 11/2/2008 12:53 AM (GMT -6)   
Some background on melatonin: You should probably ask Abbott about this question. A contact for emailing questions to them can be found at the bottom of this page:
I can't find much about the combination, but there was a report of melatonin triggering Crohn's-like symptoms in one case. There are no details about this report except an offer to sell the report for $50 to anyone interested. It appears to be a letter to the editor of some journal, so who knows whether it can be relied on. There are also positive reports citing benefits from taking melatonin for Crohn's.

Veteran Member

Date Joined Dec 2006
Total Posts : 559
   Posted 11/2/2008 1:02 AM (GMT -6)   
I have read a number of warnings about the use of melatonin by people suffering from autoimmune disorders (which should include Crohn's). The following is typical:

While the jury is still out on this one, I'd remain cautious. And it's a pity, since I have a sleep disorder and would really like to be able to take melatonin.

Crohn's since 1988
3 resections

Regular Member

Date Joined Oct 2008
Total Posts : 23
   Posted 11/2/2008 7:20 PM (GMT -6)   
I have Crohns for nearly 3 years now and it has been under control for several months now. (yay). I take melatonin a few times a week.  I dont really notice a side effect from it.  Some times (rarely) do have a hard time getting up in the morning, but i see it as i got a good night sleep.  thats more important to me.

Diagnosed with Crohns 3 years ago.
Diagnosed with RA in September.

Veteran Member

Date Joined Mar 2006
Total Posts : 1034
   Posted 11/3/2008 2:46 AM (GMT -6)   
my job has made me nocturnal for the last 3+ weeks. my body has never adjusted over completely. thus from the lack of sleep i feel like i am running on empty, my head in a cloud, and my energy levels are rock bottom. w/o melatonin, i sleep 2-3 miserable hours with no real REM, wake up for a few hours with my body feeling super fatigued but unable to sleep, then take a nap for 2-3 hours of crummy sleep again. after 2 weeks of that i began taking melatonin. i dont fall asleep any faster, but once i fall asleep i am OUT. i sleep a solid 6 hours now but it makes me groggy when i wake up, which takes a few hours to ware off. i dont use it every night as i dont want to, but being greatly sleep deprived for so long and knowing it is temporary use, i dont mind using it just so that i can semi mildly function. i cant wait to get back on the day shift. why cant the contractor just finish the darn project like he said he was going to 2 weeks ago!!!! arg.
Crazy Harry

Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07

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