I had a positive PPD back in college. My entire family tested negative, so who knows where I was exposed. I took INH for a year and now get chest xrays on regular basis. The do regular blood tests to check liver functionality. And it is a scary drug, but with Crohn's it's so important to be treated so that you can use the TNF meds. Latent TB and TNF blockers are a scary combo. Maybe you can use the dreaded steroids for the couple months until your doc says it's safe to start a TNF-alpha med? You really don't want TB on top of Crohn's... I know it's not what you want to hear, but once the TB goes into active phase (which is not unlikely on the TNF drugs) you then expose many others which get latent...
Not that you want to try Tysabri, but I was told that it does not carry the high risk of TB activation.
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 STOPPED Tysabri 10/3/08,
--currently taking budesonide suppositories, 3mg at night. Doing well with this so far.
--single mom to 11-yr-old girl