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Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 11/5/2008 11:44 AM (GMT -7)   
I am reposting a link that reports the results of a study done on children with Crohn's. There were 12 subjects and all were treatment resistant and candidates for surgery as a last resort. They had a range of IBD and I believe that 7 of them had strictures. Of the 12, 8 showed improvement with a few remissions and one of those who did not improve had their supply of the study drug accidentally interrupted and they required surgery. The biopsy study showed structural improvements at a rate four times better than steroid treatment. They were followed for 2 1/2 years.

The treatment has been determined to inhibit the proliferation of the auto-immune T cells that cause the auto-immune reaction. This has implications for other related auto-immune diseases caused by Crohn's. This includes arthritis, lupus, erythra(?) nodosum, ankylosing spondylitis, and the whole pantheon of connected illnesses. If the treatment reduces the production of auto-immune T cells, it will at least reduce the severity of the related illness.

The study drug is non-toxic and has no reported side effects. The only cautions are for people with shellfish allergies and diabetics. It has been studied as a treatment for diabetes, so presumably it only requires blood sugar level monitoring. It is not a cure, but the alternatives are few and most of those have dangerous side effects.

Link: http://www3.interscience.wiley.com/cgi-bin/fulltext/120708799/HTMLSTART

bowlies
Regular Member


Date Joined May 2007
Total Posts : 69
   Posted 11/5/2008 12:09 PM (GMT -7)   
It seems that this research was done in 2006. Do you know if there has been any follow up?

Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 11/5/2008 9:49 PM (GMT -7)   
I found that article from a related one from Science Daily: http://www.sciencedaily.com/releases/2007/05/070514132448.htm
It refers to other auto-immune diseases but talks about discoveries regarding the mode of action of the drug. It describes research showing that it inhibits auto-immune T cell growth.

Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 11/5/2008 11:19 PM (GMT -7)   
The original paper that the sciencedaily release refers to is: http://www.jbc.org/cgi/content/full/282/27/20027. It is very dense and requires specialized biochemical terminology background. It is provided so that you can see a list of articles citing this article as a source (list at the very end of the paper). If you can stomach the jargon, the Discussion section is useful. The mention of combining uridine and NAG is of interest.

Reef08
Regular Member


Date Joined Dec 2005
Total Posts : 267
   Posted 11/6/2008 8:23 AM (GMT -7)   
Wow, thanks Keeper!  I'm buying this right away!  I have a stricture in the TI and no treatments have worked so far. It's worth a shot!


Keeper
Veteran Member


Date Joined Jun 2008
Total Posts : 1058
   Posted 11/6/2008 10:39 AM (GMT -7)   
I can't see any real potential for harm and it has worked where no other treatments were working. If it uses the mechanism described, it could help a lot of other related problems as well. The usual caveats about shellfish allergies and diabetes would apply.
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