Roxette, how much Imuran are you now taking?
I've had the same problem as you -- nausea that just won't go away. I started at 50mgs per day and had no problem, but after I bumped up to 100mgs per day, I started getting nauseous all the time. I tried toughing it out for about a month, hoping it would go away, but it just kept getting worse. I went back down to 50mgs, felt better within a couple days, and then ramped up slower, going to 75mgs instead of 100mgs. I had a little nausea on 75 but not bad. But when I went to 100 again, the nausea came right back again. I'm now back to 50mgs and talking to my doctor about trying 6-mp instead.