what exactly can they tell from biopsies???

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

dustspeck
Veteran Member


Date Joined Sep 2007
Total Posts : 565
   Posted 12/3/2008 1:27 PM (GMT -7)   
i tried searching the crohn's forum, unsuccessful as usual.  i have no idea what i do wrong when trying searches!!  i have got so much on my mind right now .....
 
ANYWAYS!
 
so, when they take biopsies during a colonoscopy, what exactly are they looking for?  what can a biopsy tell them?  is it just for cancer screening?
 
any light on the subject is SINCERELY appreciated. smhair

.: stephanie :.
33 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
meddies: 6mp, percocet, trazodone, ativan, iron, calcium, folic acid & some other vits


MikeB
Veteran Member


Date Joined Mar 2006
Total Posts : 1169
   Posted 12/3/2008 2:12 PM (GMT -7)   
The pathology lab will do what is called a frozen section, where they freeze the biopsied tissue and take a very thin slice, examining it under a microscope. From that visual examination and their knowledge of what normal intestinal tissue should look like, they can detect such things as visual evidence of inflammation, granulomas (fairly unique to Crohns disease) and other abnormalities. In long standing CD they also look for cell dysplasia (changes in individual cell structure and appearance that could signal microscopic changes which could lead to cancer.) Basically the biopsy allows them to get down to cell level and see things that point to a more firm diagnosis. However, it is also important to keep in mind that the biopsies are only part of the diagnostic process -- the GI also considers clinical history (symptoms, etc,) and visual examination during the scope. The bottom line is that if you come to him with a history of cramping, diarrhea, maybe bleeding and/or weight loss . . . if he sees ulcerations or inflammation of strictures or other signs through the scope . . . and if the biopsies show inflammation and maybe granulomas, you can be pretty sure that you have Crohns. That said, if a biiopsy is taken from a non-inflamed skp area, or when you are not flaring, it may not show the same definitive signs. Like everything else ni medicine, it is a useful tool but not a sure thing.

dustspeck
Veteran Member


Date Joined Sep 2007
Total Posts : 565
   Posted 12/3/2008 2:22 PM (GMT -7)   
thanks very much mike, that was very informative. when i first was diagnosed i remember getting a pathology report stating i did have crohn's. after this last scope, i guess my intestines show no ulcerations and my strictures look minimal so that is a good thing! but now we are trying to figure out if i have ibs or something i think he called a "production" problem along with the crohn's. doesn't sound like a biopsy would say "yes, you have ibs". i am thankful that the crohn's is "in remission through an endoscopic view" but i wonder why i am still suffering with pain and still having 10+ urgent bm's a day :/ i hate the guessing game!!

thanks again.
.: stephanie :.
33 y/o female diagnosed 8/8/7 with crohn's of the terminal ileum w/ stricture/scarring
meddies: 6mp, percocet, trazodone, ativan, iron, calcium, folic acid & some other vits


downunda
New Member


Date Joined May 2008
Total Posts : 19
   Posted 12/3/2008 3:34 PM (GMT -7)   
Hi,
 
I'm having the reverse problem, my symptoms aren't that bad but my last biopsies and pathology report came back not good (no signs of cancer, but damaged cells /tissues and villi). Any thoughts on what this situation means?
Generally my thinking has been 'I'm feeling good now so enjoy it' but it may be a sign that trouble is on the horizon? 
My doc and I increased my 6MP dose around the time of the colonoscopy so I havn't changed medication since then.
 
    
 
26F, Crohn's for 8 years, currently on 6MP and pentasa. Have previously tried remicade, iron, pred and entocort.

New Topic Post Reply Printable Version
Forum Information
Currently it is Friday, December 09, 2016 12:25 PM (GMT -7)
There are a total of 2,735,434 posts in 301,303 threads.
View Active Threads


Who's Online
This forum has 151408 registered members. Please welcome our newest member, ChristineMdic.
317 Guest(s), 10 Registered Member(s) are currently online.  Details
DBwithUC, robotguy, dismissed, Girlie, reminder, LG13, Faustmann, ChickenArise, rcmark, tommyc


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer