IgA antibody question

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sr5599
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Date Joined Aug 2007
Total Posts : 1202
   Posted 12/3/2008 2:13 PM (GMT -7)   
Since the osteoporosis dx my new endocrinologist had me tested for Celiac just to make sure I can absorb properly.  The values came back for tTG as low, hence negative for Celiac.  However, my IgA was elevated...  normal is 78 - 367 and mine came back at 618.
 
Does anyone know what this means?  I am thinking that IgA is a Crohn's marker, but wanted to throw it out there and see if anyone else know.

Thanks!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 - now 2 months into it & it was the right decision
--currently taking budesonide suppositories, 3mg at night.  Doing well with this so far.
--single mom to 11-yr-old girl


beave
Veteran Member


Date Joined Mar 2007
Total Posts : 1091
   Posted 12/3/2008 2:31 PM (GMT -7)   
When testing for Celiac, doctors sometimes check IgA levels along with the tTG test.  The reason for doing this is that if somebody has an IgA deficiency, they could come back with a negative tTG test even though they really do have celiac disease.  So it's really done just to make sure the tTG isn't a false negative.
 
As for what elevated levels of IgA mean, it's a very non-specific measure.  It could mean lots of things, or nothing really.  But you are correct that it is sometimes elevated in people with autoimmune disorders, so having it elevated a bit in a Crohn's patient isn't too surprising.
 
See this link for a little more info:
 

sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 12/3/2008 8:57 PM (GMT -7)   
I guess that's what I thought. I left a message with my GI anyway just so that he'd know.
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 - now 2 months into it & it was the right decision
--currently taking budesonide suppositories, 3mg at night.  Doing well with this so far.
--single mom to 11-yr-old girl

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