Mine was a very rare deal but I stopped Imuran cold turkey because I was trying LDN (Low Dose Naltrexone). I develpoed posterior Scleritis of the eye and have been fighting it ever since. This summer I had a Gastro say "lots of wierd things happen when you come off Imuran."
As I said this my additional auto immune disease is rare but never the less still there. If I was female; wanting a baby; I would certainly stay on if my doctor agrees.