Mine was a very rare deal but I stopped Imuran cold turkey because I was trying LDN (Low Dose Naltrexone). I develpoed posterior Scleritis of the eye and have been fighting it ever since. This summer I had a Gastro say "lots of wierd things happen when you come off Imuran."
As I said this my additional auto immune disease is rare but never the less still there. If I was female; wanting a baby; I would certainly stay on if my doctor agrees.
Retired male in late 60's. Perforated Colon in 92. Diagnosed as Ulcerative Colitis in 93. Uncontrolled flareup in 97 dictated J-pouch surgery. 04 Capsule endoscopy diagnosed as Crohns not UC. Emergency surgery in 05 to remove lodged camera capsule. Biopsies positively diagnosed Crohns at that time. 12/06 Unsucessfully tried Naltrexone(LDN). 2/07 developed scleritis of the eye, tearing and detaching the retina. Treated with high doses of Prednisone. 6/07 Thought eye was healing and started taking Entocort counting on the residual (non-systemic portion) as treating the eye. Wrong. In October eye was not stabilized. 11/07 Started Remicade to try and reduce the ocular inflamation of the Scleritis since I had been requiring more and more Prednisone to keep the eye quiet. 12/07, retina tares and detaches again. Started Remicade every 4 weeks plus 20mg of Prednisone per day. Six months and seven infusions later, good eye is back to 20/14. Bad eye is 20/70. Had cataract surgery on June 05 on bad eye. Eye returned to a correctable visionary level of 20/50. 11/08 had reaction to Remicade; trying to keep going with Imuran and Pred. Need corrective eye surgery and fitted for prism lense to correct that eye from turning out. Life looks fairly good (literally) today.
Married with 4 grandkids.