Study sheds light on cause of bowel disease

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Reef08
Regular Member


Date Joined Dec 2005
Total Posts : 267
   Posted 12/8/2008 9:48 PM (GMT -7)   
 
[*I just activated the link - C2]
 
But I gotta add: I subscribe to the idea that our societies have become so "clean", our kids don't get the exposure at young age to all the "bugs" around the farm and the neighborhood, etc. Our immune systems just don't get "challenged" and the practice in combatting "things" at a young age when the immune system does most of its learning as in past years. Back then we built up an immunity or we croaked. So now more of us live longer and our immune systems have more to deal with that they haven't been exposed to or had a chance to recognize and react appropriately.

Post Edited By Moderator (CrohnieToo) : 12/10/2008 9:48:37 AM (GMT-7)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 12/8/2008 10:04 PM (GMT -7)   
Love it, thanks for posting this Reef!!

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


patientspiders
Veteran Member


Date Joined Jul 2005
Total Posts : 733
   Posted 12/8/2008 10:31 PM (GMT -7)   
Am I reading this right? Is this another vote for our immune systems/genetics being "under-active" instead of "over-active"? Well, bring on more studies, I say! It's always nice to know that SOMEONE is trying to figure us out. :-) And I find this "cause" to be as plausible as many others. Good food for thought.

Thanks for posting this article!
27f, dx'd CD July '05 after 6 fistula/abscess surgeries
(miscarried at 13 weeks, now waiting to heal before trying again)
Stopped Humira August 22nd, 2008.
Went Gluten-Free, noticing some definite improvement.
Started LDN October 27th, and already LOVING IT.

"Our greatest fear is not that we are inadequate, but that we are powerful beyond measure."


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 12/8/2008 11:58 PM (GMT -7)   
I wish they wouldn't term it "over" or "under" but instead confused immune system is more appropriate...many IBDers get colds and flus often while others don't get sick as often as a healthy person does, to me this indicates more of a confused immune system...just the way I see it for now.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Osprey101
Regular Member


Date Joined Apr 2008
Total Posts : 227
   Posted 12/9/2008 12:32 AM (GMT -7)   
There are a couple of studies that have shown improvement in Crohn's disease by stimulating the immune system. This runs counter to the theory that it's purely autoimmune.

broomhilda
Veteran Member


Date Joined May 2007
Total Posts : 1488
   Posted 12/9/2008 10:00 PM (GMT -7)   
Pb4- I like to think my immune system has Tourette Syndrome (spelling)?

Thanks Reef.
Dx'd Jan'06, 1st Resection 7/06, Humira, Imuran, B12 injections, Nexium, Lexapro, Nulev, Glucosamine, Multi-Vitamin, Calcium Citrate, Ultracet. Secondary conditions: Psorasis, Osteoarthritis, Fibromyalgia, Lactose Intolerant, gallstones, kidney stones & peri-menopausal.


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 12/9/2008 10:13 PM (GMT -7)   
LOL Broom, good one! I look at it like mine hates me.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


chocolate_stains
Regular Member


Date Joined Dec 2008
Total Posts : 61
   Posted 12/10/2008 7:40 AM (GMT -7)   
Thanks for posting Reef.

Stupid logic though. If genetics are involved in making our colons less fortified, then why does the inflammation not occur everywhere the bacteria touches the genetically weak colon? It is as simple as that.

Plus, if these boneheads are actually considering gene therapy then i guess they have not seen the disastrous deadly results of most other gene therapies. But hey, most IBD treatments come with deadly side effects, so why change that now.

Reductionist science at its best.

Reef08
Regular Member


Date Joined Dec 2005
Total Posts : 267
   Posted 12/10/2008 10:35 AM (GMT -7)   
I don't think they're trying to repair the gene, just increasing the protein that the gene produces since it's low in Crohn's patients. 
 
It's like the IL-23 gene which is found to be mutated in Crohn's patients.  There are lots of IL-23 inhibitors being used in trials now to block or neutralize the proinflammatory cytokine.  They're not necessarily trying to repair the IL-23 gene.

chocolate_stains
Regular Member


Date Joined Dec 2008
Total Posts : 61
   Posted 12/10/2008 1:02 PM (GMT -7)   
Right. And those targeted 'blockers' are equally as brutal. These things they turn off aren't just involved in the process of IBD, thus the cancers, infections, etc.

The article stating that this sheds light on "the cause" is just wrong. Genes are not THE cause of IBD; this has been established numerous times given the rapid increase in IBD; genes could not have changed this quickly to account for the rising increase in IBD. May they play a role, of course, they play a role in every disease, but to think they are the cause is insane.
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, December 05, 2016 11:01 PM (GMT -7)
There are a total of 2,733,364 posts in 301,110 threads.
View Active Threads


Who's Online
This forum has 151248 registered members. Please welcome our newest member, Lippu.
255 Guest(s), 7 Registered Member(s) are currently online.  Details
MDNative, 0311, msOuchie, roisin86, noah600, (Seashell), julymorning


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer