Tell your nurse and your doctor. All my previous Remicade infusions, they gave me Benadryl beforehand. Then I got an infusion in a different state and about halfway through I developed a sharp pain in my back. A pain that normally you could repositition yourself and it would go away. Not this time as it got progressively worse. The nurse noticed my discomfort and stopped the infusion and began squeezing saline in instead to dilute it. I saw the Dr. and then they gave me the Benadryl along with a steroid and then finsihed up the infusion.
Now my Remicade days are over as reactions tend to get worse on subsequent infusions.
I have only had two doses so far--I am still having the loading doses. Anyways, my first one was just fine. I had my second one yesterday and I had a pretty bad headache last night and into this morning. I took a few tylenol over the course of the evening/morning and it eventually went away.
When I had my first dose, the pharmacist did say I could get a headache from it. I would still tell your doctor and infusion nurse for sure!
I hope the headaches stop and that you are able to have the Remicade and have it help you!