Treatment options for rectal ulcers

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Regular Member

Date Joined Dec 2008
Total Posts : 24
   Posted 12/15/2008 1:51 PM (GMT -6)   
I’m a 42-year old female. I’ve had Crohn’s for 10 years, and was diagnosed with UC for 10 years previous to that. I had my right colon removed in Feb 07. In Oct 07, I had a colonoscopy which revealed 2 rectal ulcers. I took a 7-day course of Flagyl, which caused diarrhea, and probably aggravated the situation. After that I took Cipro, and then started Remicade in Jan 08, and continued until Sept 08 when the Remicade stopped working. The Remicade had slowly reduced the size of the ulcers. I have been in excruciating pain from BMs (4-6 per day, mushy consistency). Sometime the pain would linger all day, making it difficult to walk and sit. My GI doctor’s next recommendation for treatment is Humira. I’m reluctant to switch to this. I would like something that more directly targets the ulcers, not a long-term treatment for Crohn’s overall, because I’m not having flares.
Two weeks ago, I developed a Bartholin gland infection, and was prescribed Augmentin. In addition to healing that infection, this seems to have improved my ulcers. The extreme pain I used to feel is now 20-30 percent of what it used to be. The Augmentin was a 10-day course, and I fear the unbearable pain will return now. My GI does not want to prescribe Augmentin long-term, because of increased likelihood of C Diff. I’ve read about this bacteria, but I’m wondering if the Augmentin has tackled other bacteria contributing to the ulcers. I would appreciate any suggestions about the effectiveness of Augmentin for Crohn’s or ulcers, or other suggestions for treatment.
Thank you. -- lynn024

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 12/15/2008 2:57 PM (GMT -6)   
Anytime a Crohnie has to take antibiotics and really anytime, should be taking a probiotic at least 2 hours after your anti-b's. The Probiotics help to level out the bacterial fields in our intestines. I use a lactobacillus probiotic, and I know some others have success with Primadolphus Reuteri made by Natures Way.
Been living with Crohn's Disease for 33 years.  Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium.  Resections in 2002 and 2005.  Also diagnosed with Fibromyalgia and Osteoarthritis. Currently my Crohns is in remission.

Regular Member

Date Joined Dec 2008
Total Posts : 24
   Posted 12/17/2008 9:32 AM (GMT -6)   
Thanks for the reply, Nanners. I take Solaray Acidopholus, which has 3 types of probiotics. Anyone else with rectal ulcers who can share their experience? Thanks -- lynn024

Elite Member

Date Joined Feb 2004
Total Posts : 20552
   Posted 12/17/2008 2:10 PM (GMT -6)   
With the rectom you should be taking rectal meds to treat the inflammation and ulcers...cortifoam works best for me, ask your doc about it, I can't believe he didn't give you a script for it knowing you have proctitis.

My bum is broken....there's a big crack down the middle of it! LOL :)

Regular Member

Date Joined Dec 2008
Total Posts : 24
   Posted 12/19/2008 4:28 PM (GMT -6)   
Interesting ... my doctor hasn't mentioned any topical treatments at all. Maybe my condition is too serious for that? -- lynn024

Julia Hill
Veteran Member

Date Joined Mar 2008
Total Posts : 543
   Posted 12/19/2008 9:05 PM (GMT -6)   
Sorry to hear about your painful rectal ulcers.  Cortifoam is inserted into the rectum, and it will help some.   I also used salofalk suppositories along with the cortifoam everynight at bedtime.  When this no longer worked, I went on remicade. 
All the best to you.
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