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ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 12/16/2008 10:35 AM (GMT -7)   
I tried searching for past posts on this but couldn't find anything, so here goes.  Can't do Remicade due to allergic reactions and neither Cimzia or Humira are taking care of the joint pain.  Pain meds aren't helping enough and everything else hurts my stomach too bad to take.  GI said it's hard to know what arthritis is caused by the IBD and what is just arthritis (I'm 27, I think it's all from IBD).  He suggested maybe trying Tysabri.  Do any of you who take Tysabri have arthritis and, if so, is this helping more than the TNF blockers? 
 
Second, my thought was to try Enbrel or something for the arthritis, if the rheumy is okay with it, and use 6-mp to keep my Crohn's in remission, since the rheumy said she was seeing more results on the Enbrel for arthritis pain.  It may be stupid to mess with my crohn's treatment when I'm currently in remission.  Any thoughts on this?  I'm hurting to bad to do anything other than make it through the work day and then lay on the couch (and I used to work out 11 hours/wk).  Thanks so much!
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


CrohnsDaddy
Regular Member


Date Joined Oct 2007
Total Posts : 235
   Posted 12/18/2008 11:09 AM (GMT -7)   
I have Crohn's related arthritis, too. Right now, 150 mg/day of Azathioprine, 10 mg/day of pred and normal dosing of Cimzia are keeping most all of the arthritis pain in check. I still have some lower back pain that isn't very fun, but I haven't been on the Cimzia long enough to see if that's going to give additional help or not.

Azathoiprine is often prescribed for arthritis patients. I've gotten pretty good relief from my arthritis symptoms (in fact, better than my CD symptoms) from a TNF blocker and azathioprine.
Just trying to be a "Regular Member".


Entocort 9 mg/day, Prednisone 20 mg/day, started Humira 1/22/08, started 100 mg of Azasan (Imuran) 2/20/08. Increased Azasan to 150 mg 10/15/08. Discontinued Humira 11/03/08 after extreme fatigue and moderate muscle aches. Started Cimzia 12/4/08. Down to 10 mg/day of Pred now, and will continue to taper until completely off as long as the other meds keep me off the porcelain.



I'm convinced that Prednisone is the root of all evil, and primarily responsible for global warming.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 12/18/2008 2:01 PM (GMT -7)   
Have you tried Methotrexate? I have heard alot of folks got relief for their joint pain with that. BUT...........I have heard there can be some side effects with it. And I like you am very sensitive to medications and their side effects. My Rheumy wants me to try Enbrel too, but I am just not ready to go to the biologics. I am in a mild flare right now and have a GI appt on Tues, I am sure he is going to want me to go on 6mp. May give it a shot this time. Hope you get some relief soon, the Crohns related arthritis sucks!!!
Been living with Crohn's Disease for 33 years.  Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium.  Resections in 2002 and 2005.  Also diagnosed with Fibromyalgia and Osteoarthritis. Currently my Crohns is in remission.


ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 12/19/2008 10:10 AM (GMT -7)   
Kasper, I more I read about Tysabri, the more scared I am.  I don't think I'm ready to try it.  Nanners, I've tried 6mp but when I asked about Methotrexate, I was told that you aren't supposed to take that with a biological anymore (due to some new information out there.  I'm going to talk to the rheumy about Enbrel when I see her next month (hopefully I can get in sooner).  Thanks.
Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 12/19/2008 7:02 PM (GMT -7)   

Tysabri's response rate is ~61%.  The odds of something horrible happening in the first 3 months during which you establish efficacy are next to none.  The FDA requires a check up at 3 mo and 6 mo.  For me it didn't work.  It was unclear at the time because I continued on rectal steroids.  At 6 months the anxiety of the potential ill effects combined with the concern that it was the steroids, NOT Tysabri, helping...  I quit.  Been better on the steroids alone (since I can take them daily, rectal budesonide).

If you really feel like you want to try Tysabri and the other treatments have not worked, it's worth a try.  Once you figure out if it works you could determine whether it's worth the risk.  If you don't feel like you can emotionally handle the risk, that's ok too.  It's a very personal decision. 


--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 - now 2 months into it & it was the right decision
--currently taking budesonide suppositories, 3mg at night.  Doing well with this so far.
--single mom to 11-yr-old girl

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