effectiveness of methotrexate

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Chronicallyill
Regular Member


Date Joined Apr 2008
Total Posts : 195
   Posted 12/16/2008 3:34 PM (GMT -7)   
Hello everyone. I have been on methotrexate pills since the beginning of November. They seemed to work at first and dont seem to be working at all now.  Also thinking that it could have been the one IM shot that helped and lasted that whole time, which i thought that the pills were working. Anyone taken methotrexate orally and found that it stopped being effective?
 
Nessa
Age:22/6"1'/146lb - Diagnosed: 2001 @ age 15 now 22
First time mom as of March 8th 2008
Past drugs: Pentasa, Flagyl, Budesonide, Prednisone, tons of Antibiotics, Didrocal, 6mp
Past herbal remedies and vitamins:Probiotics, Omega 3&6, Prenatal vitamins, B12, Calcium, iron, vit C, vit D, vit E, Selenium, mineral drops
Current drugs: Valtrex, Methotrexate as of October 2008
Problems:Fissure and Tags on rectum, blood clots, Chronic UTI's, Osteopenia, Ulcers in my decending Colon
No surgeries....yet. Gone through 5 G.I.'s found a 6th G.I. crossing my fingers
Procedures: 4 colonoscopies, 1 upper endoscopy, 2 barium swallows, 1 biopsy of the fissure and tag (chron's affected)


78SilvAnniv
Regular Member


Date Joined Apr 2008
Total Posts : 289
   Posted 12/16/2008 7:44 PM (GMT -7)   
Me. 
I began with 6 weeks of IM shots and then switched to pills.  Both the pills and the shots were given/taken only once a week.  Tuesday is my chosen day.  With the IM shots, I had almost immediate results and very little/no nausea.  When I switched to pills, the nausea came on very strong and my symptoms (loose stool, gas, mucus, multiple bathroom trips) came back.  My GI put me back on the IM injections and I do them myself at home.  I am still having difficulty with nausea, but it isn't as bad as when I was taking the pills.
 
For my first 6-week course, I went to an Oncologist office for the weekly shots...at $30 co-pay each visit... mad    I asked my GI Dr if I could give myself the shots at home, and now, for $10 I've got my 4 injections/mo covered and they are easy to give to myself.  Today was my second IM shot.  I can tell that my loose stool is trying to firm up, but I still had an 'underwear accident' today within 5min of me leaving the house to do some shopping.  Quick turn-around to home for clean-up, soiled clothes in the laundry and fresh clothes saw me back on the road again to complete my shopping. 
I won't let Crohn's stop me from doing what I want to do.
Heidi
I have the ability of single-minded determination and accurate project focu....Hey, look, a cat!
 
Crohn's and UC are pretty darn crappy, but if you can't laugh at yourself, you'll cry. 
I'd much rather laugh.
2001 Dx'd with UC.  No remission.  5/2008 surgery, removal of 6" of left side colon.  Dx changed to Crohn's.  Remission for 8-9wks after surgery, symptoms returning after resuming 6MP.


indigosunrise
Regular Member


Date Joined Nov 2007
Total Posts : 497
   Posted 12/16/2008 8:02 PM (GMT -7)   
I was on the oral MTX for about 4 months and it didn't do anything for me. I never tried the shots and I would be curious to see if they work better.

I work for a college of pharmacy and I asked one of our pharmacists there why the MTX may not have worked for me. She said that a small percentage of the population, about 5%, is lacking an enzyme needed to break down the MTX so the body can use it. She believes I may be lacking in this enzyme. Anyhow, I just thought that was interesting.

I DO have the necessary enzyme for Imuran so I have been on that drug for about 3 months now.

Best of luck to you and I hope you feel better soon!

Chronicallyill
Regular Member


Date Joined Apr 2008
Total Posts : 195
   Posted 12/16/2008 8:05 PM (GMT -7)   
I had one shot IM and since i have taken it orally. We are switching to IM again but not sure when. The pills messed with me for sure. I thought I was pregnant which scared the crap out of me. I was regular after I had my daughter, finally for once in my life lol. Then I started Metho and I was 9 days late and feeling nauseas. So it kind of scared me that way. I stopped for a couple weeks and that made things really bad and i am still feeling like crap :(. Its 100 dollars a month for my 4 shots so trying to see if I can get it covered.
Age:22/6"1'/146lb - Diagnosed: 2001 @ age 15 now 22
First time mom as of March 8th 2008
Past drugs: Pentasa, Flagyl, Budesonide, Prednisone, tons of Antibiotics, Didrocal, 6mp
Past herbal remedies and vitamins:Probiotics, Omega 3&6, Prenatal vitamins, B12, Calcium, iron, vit C, vit D, vit E, Selenium, mineral drops
Current drugs: Valtrex, Methotrexate as of October 2008
Problems:Fissure and Tags on rectum, blood clots, Chronic UTI's, Osteopenia, Ulcers in my decending Colon
No surgeries....yet. Gone through 5 G.I.'s found a 6th G.I. crossing my fingers
Procedures: 4 colonoscopies, 1 upper endoscopy, 2 barium swallows, 1 biopsy of the fissure and tag (chron's affected)


indigosunrise
Regular Member


Date Joined Nov 2007
Total Posts : 497
   Posted 12/16/2008 8:13 PM (GMT -7)   
I hope you feel better soon!

I have heard Methotrexate can be a very good drug--I was really disappointed it didn't work for me. I hope you will be able to get the shots covered as well.

Cookie's Wife
Regular Member


Date Joined Aug 2005
Total Posts : 299
   Posted 12/16/2008 8:13 PM (GMT -7)   
Chronically- I would call around for pricing. I don't have insurance and I pay $27 for a two month supply. I just had my 5th shot and so far so good! Pills weren't mentioned by my GI and I do the shots at home. Good luck!
~April~
 
"A woman's heart should be so lost in God that a man needs to seek Him in order to find her..." <3

 



Chronicallyill
Regular Member


Date Joined Apr 2008
Total Posts : 195
   Posted 12/16/2008 8:29 PM (GMT -7)   
Well the government usually covers all my scripts but because this is another option of methotrexate it is not covered. Because its not the first choice they expect you to pay. Grrrrrrrrrrr. Shots arent so bad either. :) I had to take 2 shots a day for 2 1/2 months when I was 7 months pregnant for blood clots in my lungs so once a week won't be so bad lol.

Age:22/6"1'/146lb - Diagnosed: 2001 @ age 15 now 22
First time mom as of March 8th 2008
Past drugs: Pentasa, Flagyl, Budesonide, Prednisone, tons of Antibiotics, Didrocal, 6mp
Past herbal remedies and vitamins:Probiotics, Omega 3&6, Prenatal vitamins, B12, Calcium, iron, vit C, vit D, vit E, Selenium, mineral drops
Current drugs: Valtrex, Methotrexate as of October 2008
Problems:Fissure and Tags on rectum, blood clots, Chronic UTI's, Osteopenia, Ulcers in my decending Colon
No surgeries....yet. Gone through 5 G.I.'s found a 6th G.I. crossing my fingers
Procedures: 4 colonoscopies, 1 upper endoscopy, 2 barium swallows, 1 biopsy of the fissure and tag (chron's affected)

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