Stem Cell Research

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vtpaleface
New Member


Date Joined Oct 2008
Total Posts : 2
   Posted 12/22/2008 7:58 PM (GMT -7)   
I have had crohn's for 27 years now and I have tried all kinds of treatments, none that have worked very well for me. I have been recently approached by my GI doc about a joining a study of stem cells for crohn's disease. I would like to hear what if any of you out there is on the study and what there feelings about it are.

pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 12/22/2008 9:15 PM (GMT -7)   
My feelings about it are I wish they'd hurry up already and I'm not impressed that they are only looking at using it for those that are at the severest stages of their IBD...it should be used for all IBDers even those who are maintaining remission on meds because those meds can be killer.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 12/22/2008 9:22 PM (GMT -7)   
To elaborate on more info about stem cell and IBD, this is from the CCFC "Ask the Doctor" (he happens to be my GI)....

Stem Cell Research

DEAR DOCTOR: We hear so much about stem cell research in the media; can you tell me what it is and whether it has any application or benefit for people with IBD? Are there any investigations using this approach?

DEAR CCFC MEMBER: In order to answer this question one needs to understand the technology
and the debate over this technology. Stem cells are cells that are able to differentiate into specialized cell types but also retain the ability to renew themselves through cell division. Stem cells were first dentified in embryos. In an embryonic blastocyst, stem cells of the inner cell mass proceed to develop into all of the tissues and organs of the body. In adults, progenitor cells and possibly multipotent adult stem cells act as a repair system for the body, replenishing more specialized cells.The existence of truly luripotent stem cells in adult humans beings is still scientifically controversial. The use of stem cell transplantation using an autologous transplantation (deriving stem cells from one’s own bone marrow and then re-transplanting as they do in leukemia and lymphoma) has been attempted in many autoimmune diseases including Crohn’s disease.The largest series has been done by Northwestern University in Chicago with some promising results in a small, limited, and highly select group of patients. However, the results have sparked enough interest that several large IBD centers across the world including the University of Calgary and the University of Alberta are looking into studying this further. An alternative strategy to an autologous translpant is using adult mesenchymal donor cells.This is being investigated by a pharma company in which patients will receive two treatments of adult mesenchymal stem cells for the the treatment of Crohn’s disease. These cells are like receiving Type O blood (they are universally accepted) into the host. The hope is that this therapy will help heal damaged intestine.


:)
My bum is broken....there's a big crack down the middle of it! LOL :)


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 12/22/2008 9:57 PM (GMT -7)   
is this a Prochymal study or a stem cell transplant study (Northwestern Univ)?
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 - now 2 months into it & it was the right decision
--currently taking budesonide suppositories, 3mg at night.  Doing well with this so far.  Dx Osteoporosis 10/08 waiting to start Forteo (pending approval)
--single mom to 11-yr-old girl


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 20576
   Posted 12/22/2008 10:18 PM (GMT -7)   
I don't know, I read it as a stem cell transplant study.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


Osprey101
Regular Member


Date Joined Apr 2008
Total Posts : 227
   Posted 12/22/2008 10:36 PM (GMT -7)   
Clinicaltrials.gov says there are 8 trials currently recruiting volunteers with Crohn's for studies involving stem cells, if anyone is interested.

http://clinicaltrials.gov/ct2/results?term=Crohn%27s+stem
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