I am one of the folks who has Crohns, Fibromyalgia and Osteoarthritis. The only med I use for the Fibro is my pain medicine. That is the only thing that helps me. My Rheumy wants me to take one of the biologics, but I am just not ready to go there right now. The pain meds and muscle relaxers seem to work well enough. But at least I know those meds are there if I ever feel thats the way I have to go. Hope that helps.