Remicade vs Methotrexate vs ???

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dietcoke
Regular Member


Date Joined Jul 2008
Total Posts : 186
   Posted 12/29/2008 8:57 AM (GMT -7)   
Hi! I am wondering if anyone has advice for me. I have had Crohn's disease for about 10 years now. I have been on most medications and have not had much luck on any of them (including Asacol and 6MP both of which I was hospitalized from). The only med that has given me relief aside from Prednisone is Cipro, which no longer works.

I have now been on Humira since May, increased my dosage to weekly injections about a month ago, and it still has not done anything for me.

My doctor says my next two options are Remicade or Methotrexate, neither of which really excite me if you know what I mean. Which would you choose? And, are there any other options out there for me that others have had success with (aside from the SCD and Maker's Diet.)

Thanks so much for your help. I feel like I am running out of options.
Ps - I am a 39 year old female with one child, and would like to have another if I'm able.
39 years old female, Dx'd 2000 Crohn's Colitis in entire colon
Allergic to Asacol/Pentasa/6MP/Immuran and many others (too many to remember)
Past meds: Cipro, Pred
Current meds: Humira (...and waiting for it to work)


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 12/29/2008 9:00 AM (GMT -7)   
I have heard a few folks have had success with Cimzia when Humira no longer worked. Hope that helps.
Been living with Crohn's Disease for 33 years.  Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium.  Resections in 2002 and 2005.  Also diagnosed with Fibromyalgia and Osteoarthritis. Currently my Crohns is in remission.


dietcoke
Regular Member


Date Joined Jul 2008
Total Posts : 186
   Posted 12/29/2008 10:45 AM (GMT -7)   
Yes, I've heard that Cimzia has worked for people as well. Also, Cimzia scares me for some reason. Not that Humira, Remicade and Methotrexate don't...
39 years old female, Dx'd 2000 Crohn's Colitis in entire colon
Allergic to Asacol/Pentasa/6MP/Immuran and many others (too many to remember)
Past meds: Cipro, Pred
Current meds: Humira (...and waiting for it to work)


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 12/29/2008 10:56 AM (GMT -7)   
I think it is CrohnsDaddy who has a journal post of his trial with Cimzia. He seems to be doing really well on it. I hear you on the biologics, for some reason they scare me too, but I would use them if I got to that point.
Been living with Crohn's Disease for 33 years.  Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium.  Resections in 2002 and 2005.  Also diagnosed with Fibromyalgia and Osteoarthritis. Currently my Crohns is in remission.


dietcoke
Regular Member


Date Joined Jul 2008
Total Posts : 186
   Posted 12/29/2008 11:00 AM (GMT -7)   
Thanks, I will look at his post. I have been on Humira for eight months, but it's not helping at all, so I have one biologic down (I think that's a biologic). A few more to go I guess.
39 years old female, Dx'd 2000 Crohn's Colitis in entire colon
Allergic to Asacol/Pentasa/6MP/Immuran and many others (too many to remember)
Past meds: Cipro, Pred
Current meds: Humira (...and waiting for it to work)


bektold
Regular Member


Date Joined Jul 2007
Total Posts : 456
   Posted 12/29/2008 12:13 PM (GMT -7)   
If you are, or plan to be, pregnant you should absolutely not take methotrexate.  It's sometimes used to induce abortion in early pregnancy, and can cause birth defects if the fetus survives.  Definitely not something you want to risk taking during pregnancy.
 
Remicade was helpful to me at first, but a year in I don't feel that my overall condition has improved that much.  I've had to bump from every eight weeks to every six week because the treatments weren't lasting long enough.  I'm also taking methotrexate, which I'm also not that impressed with.  For the first month or two it helped, but it seems like I'm back sliding again.  I've also been having problems with sinus and ear infections lately, which was not an issue a year ago with the Remicade/Imuran combo I was on at the time.  I'm not sure where I'm going from here.  I'm willing to try Cimzia if one of my doctors will prescribe it.

Miss3
Regular Member


Date Joined Sep 2008
Total Posts : 97
   Posted 12/29/2008 2:19 PM (GMT -7)   
I got progressively worse from asacol. Remicade gave me aweful side effects. I'm currently trying low dose naltrexone. Just another option you may want to look in to.
 
 
Good luck,
 
Miss
 
LDN


dietcoke
Regular Member


Date Joined Jul 2008
Total Posts : 186
   Posted 12/29/2008 2:36 PM (GMT -7)   
Hmmm. Never heard of low dose naltrexone. I will look into it. Please keep me posted on how you are doing. Thanks!
39 years old female, Dx'd 2000 Crohn's Colitis in entire colon
Allergic to Asacol/Pentasa/6MP/Immuran and many others (too many to remember)
Past meds: Cipro, Pred
Current meds: Humira (...and waiting for it to work)


Miss3
Regular Member


Date Joined Sep 2008
Total Posts : 97
   Posted 12/29/2008 2:51 PM (GMT -7)   
I only heard about LDN because there's a local trial going on where I am located in PA. They are currently doing a second study at Hershey Medical Center and I looked into it but didn't want to end up with the placebo lol. So my family MD here prescribed it for me. I've been at full dose for a little over a month, nothing miraculous to report yet but most see improvement from 60-70 days so we'll see. I should see some improvement by the end of January or so if it will work for me. Two thirds claim total remission, would be nice!
 
Miss
 
 
LDN


tsitodawg
Veteran Member


Date Joined Sep 2006
Total Posts : 845
   Posted 12/29/2008 3:43 PM (GMT -7)   
I have been on remicade, methotrexate, humira, 6-mp, and am currently on cimzia. Although methotrexate seemed to give me some relief of my joint arthritis, it caused me to have some liver damage and pancreatitis. When I was on remicade, we used 6-mp and methotrexate in order to help the remicade. 6-mp actually helped me feel the best, but it also caused me to have elevated liver levels. I was on remicade for 3 1/2 years and got to the point that we could not up the dosage or increase the frequency of infusions. I then went to humira but got so sick during the loading process that I had to be taken off of it and went back to my monthly remicade infusions. This bought me about another year until I built up antibodies toward remicade and got syrum sickness. I was then on prednisone for 6 months until the FDA approved cimzia for use with Crohn's. I have been on it since October and have noticed some good things, but it does have side effects that comes with it. It actually reminds me of being on remicade. I noticed that you mentioned that you were a little afraid to try it, but since you are already on Humira you should not be to worried. It has about the same side effects and warnings as Humira and Remicade. They are very similar to being the same medications but without the mice protein that remicade uses and a little different mixture than what Humira is. The worse side effect that I have had is muscle/bone ache and nausea for a week or so after the injection. It is a little bit of an inconvinience to have a home healthcare nurse come and administer it, but now I look forward to our conversations as we wait for the medication to mix.(about 1 1/2 hours) Have you tried remicade yet? Most insurance companies require that you have failed both Remicade and Humira before they approve you to use Cimzia. Of course, this makes no sense since Remicade is about double the cost of the Cimza and Cimzia give you the first 3 doses for free with financial assistance for the next 6-12 doses.
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