Azathiprine/Liver

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robwise
Regular Member


Date Joined Dec 2003
Total Posts : 109
   Posted 12/30/2008 11:12 AM (GMT -7)   
For the past year my CBC has shown my liver profile to be steadily increasing.  This didn't start happening until my azathioprine was increased from 75 mg day to 100 mg day.  I'm still not in therapeutic range.  How abnormal should it be before I stop azathioprine?
 
Alk Phosphatase = 52
(SGOt) AST= 75
(SGPT) alt= 59
 
What about fatty liver? Is that anything to be concerned about?
 
If my liver is not working correctly? I assume that is why some other results are abnormal.
Diagnosed w/Crohn's Disease 1988.  One resection at Terminal Illium.
Medications:
4 g - Pentasa
75 mg - Azathioprine
40 mg - Humira
B12 injections monthly
Effexor
Actonel
various supplements


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 12/30/2008 1:06 PM (GMT -7)   
Really more of a doctor question Rob. But generally, when lever enzymes go up you have to decrease your dose. I don't think fatty liver is a huge deal.
Dx'ed in 1999. No surgeries.

Current meds: 25mg Methotrexate. 12.5mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 12/31/2008 4:23 PM (GMT -7)   
What is your GI saying about the issue? Also, sometimes switching from azathioprine to 6MP decreases the liver problems. Not always, but in some people it works. I'd pin my GI down about the rise in liver values, state my concerns and work out a plan regarding it. Good luck.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 

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