methotrexate ineffective? ? ? ? ?

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Regular Member

Date Joined Apr 2008
Total Posts : 195
   Posted 1/8/2009 12:04 AM (GMT -6)   
the methotrexate has just stopped working. I don't understand and I am so frustrated right now. My bowel is going crazy and I dont know what to do. I will no longer touch Pred or 6mp ever again. I just started this in October and have recently started the shots. I had my first dose as a shot and then went to pills, which were ineffective so that why i am doing shots again, but still not even a little bit of relief.
It helped the first two weeks, but isnt anymore. I want to try LDN, but my docs here in Canada won't even consider because there isn't enough data and research on it and crohn's. Grrrrrrrrr so frustrated.
Age:22/6"1'/146lb - Diagnosed: 2001 @ age 15 now 22
First time mom as of March 8th 2008
Past drugs: Pentasa, Flagyl, Budesonide, Prednisone, tons of Antibiotics, Didrocal, 6mp
Past herbal remedies and vitamins:Probiotics, Omega 3&6, Prenatal vitamins, B12, Calcium, iron, vit C, vit D, vit E, Selenium, mineral drops
Current drugs: Valtrex, Methotrexate as of October 2008
Problems:Fissure and Tags on rectum, blood clots, Chronic UTI's, Osteopenia, Ulcers in my decending Colon
No surgeries....yet. Gone through 5 G.I.'s found a 6th G.I. crossing my fingers
Procedures: 4 colonoscopies, 1 upper endoscopy, 2 barium swallows, 1 biopsy of the fissure and tag (chron's affected)

Rider Fan
Veteran Member

Date Joined May 2008
Total Posts : 1445
   Posted 1/8/2009 10:22 AM (GMT -6)   
It took me 8 weeks of 25mg shots to notice a difference. I also noticed an improvement when I went from 3mg of folic acid to only 1mg. I think it's common for the pills to not work as well as the shots, try to give them 2-3 months in you can.
Dx'ed in 1999. No surgeries.

Current meds: 25mg Methotrexate. 12.5mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.

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