update, Marie- 15 years old. 6mp versus methotrexate !!!!!Help

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55555jlw
Regular Member


Date Joined Dec 2008
Total Posts : 103
   Posted 1/15/2009 5:15 PM (GMT -7)   
My daughter has been given the option to choose between 6 - MP and shots of Methotrexate. Any and all opinions welcome.

Jennifer
DX in 2000,  on Pentasa only :)
daughter age 15 newly dx with Crohn's
 
 


RightOutStraight02
New Member


Date Joined Jan 2009
Total Posts : 15
   Posted 1/15/2009 5:54 PM (GMT -7)   
According to my GI, 6mp is the most popular of the two, not sure for what exact reason. It could be beneficial to give 6mp a shot first because it is a pill as opposed to having to get injections of the Methotrexate. From what I understand from my GI they are very closely related drugs and the differences between them is not major. Some people don't do well with 6mp in terms of side effects and so try methotrexate in stead.
20 years old.
Dx'd with Crohn's at the age of 13.
Dx'd with Fibromyalgia at 15.
Currently taking 6mp and Flagyl.
10 inches of my small intestine removed October 2008.
When will remission come?!?!
 
Best regards to everyone here, bless you all.


cbk
Regular Member


Date Joined Apr 2007
Total Posts : 134
   Posted 1/15/2009 6:01 PM (GMT -7)   
well the choice is difficult, mostly because of her age.

i've been on both..and there are differences to take into consideration.

i would begin with the 6MP because its less "toxic" than MTX. also, as 15-year-old, taking pills will probably be the less scary option for her.

if 6MP does not work out, or beings to loose its effectiveness, MTX should be your next choice. I've been on it a year or so, and its done its job. No alcohol on it (or only a few beers a week, which she will have to be aware of later in high school and college). Also, she definately needs to be on birth control if she's on MTX...I'm not going to say too much more about that choice.

Both have potential serious side effects, but its exceptionally rare. The major issue with 6MP are lymphomas and with MTX liver damager (they did discover that psoriasis patients are more prone to this).

Both my doctors have expressed to me that if they had this disease they would opt for MTX...it's safer than the biologics and for females more effective in treating fistulas, which is something else you have to consider.
22 Female, currently on MTX. Previously on Imuran, Remicade, Pentasa, etc. Ileocolic resection in 2006.


cbk
Regular Member


Date Joined Apr 2007
Total Posts : 134
   Posted 1/15/2009 6:05 PM (GMT -7)   

and one last thing..

a lot of the current research states that using more aggressive treatment from the start of the illness prevents surgeries and leads to a better long term prognosis...this makes the case for MTX.


22 Female, currently on MTX. Previously on Imuran, Remicade, Pentasa, etc. Ileocolic resection in 2006.


55555jlw
Regular Member


Date Joined Dec 2008
Total Posts : 103
   Posted 1/17/2009 7:58 PM (GMT -7)   

Thaks so much for yoru responses.  I think we are actually leaning on useing Pentasa only for a while, tapering off prednisone and seeing what happens.  With all the side effects, we are just going to take it slowly.  Should she have a relapse we will follow the doctors orders, but until then we are going to research some natural remedies.

Jennifer


DX in 2000,  on Pentasa only :)
daughter age 15 newly dx with Crohn's
 
 


73monte
Veteran Member


Date Joined Mar 2007
Total Posts : 1499
   Posted 1/18/2009 3:50 AM (GMT -7)   

Jennifer,

I don't blame you a bit for going the route you are. These medication choices present a scary proposition, especially considering you're making decisions for your child. It's one thing to have a bad reaction to a medication that you choose for yourself, but to do that to your daughter is difficult to live with. 

You and I are in similar situations, with daughters about the same age. You have more experience with all of this since you have been coping with the disease personally as well.

I too, would like to keep my daughter on Pentasa, after this current round of Prednisone. We did that for the last 2 yrs., but looking back, I can see that the disease was brewing during that time. But none the less, she was apparently healthy and thriving for that 2 yrs. Hopefully, you can do this with your daughter, as it's a very safe medication. You just don't want to accelerate the cycle and have to contiuously resort to Prednisone to get things under control. That's what I'm wrestling with right now. 

I'm not sure yet which route we're going to take, (they want to try Imuran/same as 6MP).  

How is she doing now on Prednisone? When my daughter first went on it, I thought it was a miracle drug, but of course I realized quickly that you have to have alot of respect for it. I seem to remember that you were worried about her size. If it's any consolation, my daughter is still growing. Two yrs. ago she looked like she should be in Grade 3, now almost 5'6". I understand that this is very typical, so I don't think you have to worry. Good luck with everything. 

Tom.


My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Initially, 9 weeks of Prednisone, currently taking 2000mgs of Pentasa.


cbk
Regular Member


Date Joined Apr 2007
Total Posts : 134
   Posted 1/18/2009 1:38 PM (GMT -7)   
I don't want to be a Debbie Downer, but if the doctor suggested that your daughter consider taking either of these two medicines, her disease is serious. Natural "remedies" and "therapies" are a nice idea, but frankly Crohn's requires more than dietary changes and supplements.

That being said, it's important to remember that the earlier and more aggressively you treat Crohn's the more likely it is to be put in remission for longer periods of time and avoid surgeries. Your daughter may feel great initially from the natural method, but its just a masking for what's going on internally...

I had symptoms of Crohn's when I was around your daughter's age and our first response was to do the natural thing, but all it did was delay the inevitable.

Don't get me wrong, I absolutely agree that patients with chronic illness incorporate alternatives into their lifestyle, but synthetic drugs are undoubtedly necessary.
22 Female, currently on MTX. Previously on Imuran, Remicade, Pentasa, etc. Ileocolic resection in 2006.


55555jlw
Regular Member


Date Joined Dec 2008
Total Posts : 103
   Posted 1/18/2009 3:56 PM (GMT -7)   

Thanks for your honest response.  I am just so confused.  I don't want her to become infertile or get Cancer from these meds if she is lucky like me and can just use pentasa.  I will think and pray about his and appreciate your honesty.

Jennifer

 


DX in 2000,  on Pentasa only :)
daughter age 15 dx with Crohn's on 12/22/08:  Prednisone, Nexium, Pentasa
 
 


FallColors
Veteran Member


Date Joined May 2007
Total Posts : 1220
   Posted 1/18/2009 4:48 PM (GMT -7)   
Please keep in mind that it will take time -- months -- to work up to the therapeutic dose of 6MP. First you get a blood test to see if you have a specific protein. Then you start will a small dose and use blood tests to show when you can increase the dose. Once at the theapeutic dose, you will get blood test every 3 months will show that you are still on track. So the sooner you start, the sooner you will get help from the drug. The blood tests will also monitor whether there are any ill effects. I suggest she take it before bed because a common side effect is sleepiness.
Diagnosed early 2007 with rectal Crohn's.  Several peri-rectal abscesses and two fistulas with setons.  Allergic to Remicade and Humira.  Currently on 6MP.

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