blood test for lupus

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ERANJO
Regular Member


Date Joined Apr 2008
Total Posts : 60
   Posted 1/19/2009 6:15 AM (GMT -7)   
Hi everyone,   i havent posted in a while, actually been feeling better since my surgery in July..I am still on Humira for 1 year now...but recently I have been feeling like crap, every single bone in my body aches, I am beyond tired all the time, no matter how much sleep i get. tylenol does NOTHING to help, I am scheduled to see my rheumy on thursday and I wanted to ask him about that blood test that i read about on here before about humira induced lupus....can anyone help?
 
Kelly confused

MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 1/19/2009 6:20 AM (GMT -7)   
try getting an ANA test done....
Forum Co-moderator - Crohn's Disease
...I will find a way, or make one. -Philip Sidney 1554-1586
All that I am and all that I shall ever be, I owe to my Angel Mother.
Make sure your suffering has meaning...
All suggestions/options/opinions are caveated with please consult with your local health care provider...


ERANJO
Regular Member


Date Joined Apr 2008
Total Posts : 60
   Posted 1/19/2009 6:23 AM (GMT -7)   
Thats what it was...i will, thank you

Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 1/19/2009 8:35 AM (GMT -7)   
Sure seems like a lot of people get lupus (temporary or permanent) from these biologics. Is Humira worse for this than remicade?
Dx'ed in 1999. No surgeries.

Current meds: 25mg Methotrexate. 12.5mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


Ides
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Date Joined Nov 2003
Total Posts : 7077
   Posted 1/19/2009 4:58 PM (GMT -7)   
Besides an ANA, the rheumy hopefully will also draw titers for anti-dsDNA antibodies and SSA and SSB Autoantibodies. I had a high anti-dsDNA titer and negative ANA. The anti-dsDNA is an antibody specific to lupus and the one most commonly seen in drug-induced lupus.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


ERANJO
Regular Member


Date Joined Apr 2008
Total Posts : 60
   Posted 1/20/2009 3:58 AM (GMT -7)   

thank you... i am gonna print out your response and bring to my rhuemy...cause i know myself, I"ll tell him the wrong thing

thanks everyone, Kelly

 


dunny2
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Date Joined Jan 2007
Total Posts : 3200
   Posted 1/20/2009 8:44 AM (GMT -7)   
Ides, I'm the opposite way round to you. My anti-dsDNA antibodies was negative, which would suggest that I'm not drug induced, but
my ANA titer levels and my double stranded DNA were extremely high. I find all this so confusing... I was so sure this was drug induced.
Vicky

Too many years with CD
Two bowel resections, several obstructions.
Fibromyalgia and recently diagnosed with chronic pancreatitis and lupus.
B12 Shots bi-weekly

Laughter is the brush that sweeps the cobwebs from our hearts...


MMMNAVY
Veteran Member


Date Joined Jul 2006
Total Posts : 6927
   Posted 1/20/2009 9:06 AM (GMT -7)   
drug induced vs. autoimmune cascade
Forum Co-moderator - Crohn's Disease
...I will find a way, or make one. -Philip Sidney 1554-1586
All that I am and all that I shall ever be, I owe to my Angel Mother.
Make sure your suffering has meaning...
All suggestions/options/opinions are caveated with please consult with your local health care provider...


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 1/21/2009 12:44 PM (GMT -7)   
dsDNA = double stranded DNA

So Dunny - the test run for anti-dsDNA antibodies is called DNA Double Strand. There are two different methods of running the test so other letters or words can follow the DNA Double Strand listing on the lab report.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


mimik81
Regular Member


Date Joined Jan 2008
Total Posts : 88
   Posted 1/27/2009 9:50 PM (GMT -7)   
I just posted something about this in another strand.

I developed "drug-induced lupus" about six months after I started Humira. I have been off of it for about 6 months, and the lupus symptoms are now worse than my Crohn's.

I started with very bad joint pain, awful headaches, chest pain, and fatigue. It took awhile before I got the docs to run the ANA test, which came back showing it was lupus.

I was optimistic at first, but now, I think I'm stuck with a new autoimmune disease. It's unfortunate because my Crohn's was more than enough to deal with - having this is just making my life even more miserable. There are days when I can barely get off of the couch, and I now have a lot of kidney problems.

Good luck, and trust your instincts. I know when things are going on with my body, and although it took awhile, I finally found a doctor that was willing to listen to what I had to say, and he got on the ball and did some testing.
Diagnosed with Crohn's for 13 Years
Currently on 75 mg Imuran

Tried prednisone, flagyl, pentasa, and Humira (developed drug-induced lupus and had to stop).


caroline_r
Regular Member


Date Joined Apr 2004
Total Posts : 94
   Posted 1/29/2009 7:26 AM (GMT -7)   
Rider Fan said...
Sure seems like a lot of people get lupus (temporary or permanent) from these biologics. Is Humira worse for this than remicade?


The same thing happens with Remicade, since their both anti-TNF drugs. Both can induce Lupus-like syndrome but if you have a genetical predisposition for Lupus then you will get the actual Lupus if you take Humira or Remicade. Just like something has to trigger CD, something has to trigger Lupus...in this case it's Humira or Remicade. So if any of you know that someone in your family has had Lupus go check to which diseases you have genetical predisposition and if Lupus is one of them don't take Humira or Remicade or any other anti-TNF drug.

As for which is worse...Humira or Remicade, I'd really like to know that. But it's reall hard to tell since they're very very similar. Humira is human, and Remicade has 25% of mouse genes. Remicade has more side-effects but Humira hasn't been tested as long as Remicade so it's not really fair to say R has more side-effects, but mostly you'll read the same things about both meds.
21 yr. old with crohn colitis. Diagnosed in March 2004. No surgeries so far.

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