I have my infusion every 6 weeks. From the time I arrive to the time I walk out the door it takes about three and a half hours. The actual infusion may only take about two hours, but they don't start mixing until after you get there and weigh in, and then they take a little time when it's done to be sure you're OK.
From the beginning I saw an immediate difference after my infusion. I used to feel a little tired afterwards, but that isn't so bad any more. I've never had the achey, flu-like symptoms that some have. For the last two infusions I've had a little bit of bleeding in the days after, though. I was particularly disappointing to see that blood today, since I had my infusion on Thursday and started a short course of Pred today for my Rheumatologist.