I hear ya girlfriend! I've had Crohns for 25 years, I'm 45, so that's most of my adult years. I started out on the usual drugs: prednisone, azulphadine, asacol, pentasa.... you name it-Ive probably taken it. Except for Imuran. I've been receiving Remicade infusions since 1999. Sometimes they work better than other times. In 2004, I lost one of my sisters to cancer, and three months later, I lost my mother. I don't think they have a drug for that kind of thing. Anyways- if you haven't tried Remicade, maybe you should ask your GI guy about it. It's been around for a long time. That's what I liked about it. Some of the stuff that comes out today will kill you 6 months from now even though they say it's safe. And so far, after 10 years, I haven't grown a third eye or anything like that. However, it does seem to have lost some of it's umph. I started out getting infusions every 8 weeks. Now I'm down to every 4 weeks, and that is why my GI guy wants me to have surgery. This will be my first surgery for Crohns in 25 years, so in that aspect I feel very fortunate. I'm new to this site as well, but I can tell you-it's the best thing since sliced bread! I have a great support system in my family, but even though they understand, the folks here feel your pain-really they how you feel. Sometimes it helps me to just have a third party listen to all my whines and cries, then I'm good to go for a while. You should try that too. Let me know how it goes.