Increasingly bad Humira injection site reactions

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New Member

Date Joined Nov 2008
Total Posts : 17
   Posted 2/6/2009 1:07 AM (GMT -6)   
I've been on Humira for the first 4 shots...the following 2 shots...then every other week 1 shot for 5 shots. The last 4 have given me injection site reactions. They have been getting worse wirh each shot. First it was just a the last 2 swell up and itch for 1 or more weeks...this last one is swollen larger than my open outstretched hand...what can I do to help this?

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 2/6/2009 1:15 AM (GMT -6)   
First, Aguagirl, please know that you're not alone in this. It has happened to many people on this forum.

Two things that have helped me:
* take an antihistamine before injecting
* stop icing! For me, at least, icing before the injection just made the reaction worse.

The others might have some different tips for you.

Best wishes, and welcome to the forums,

Co-Moderator Crohn's Forum.

Veteran Member

Date Joined Oct 2008
Total Posts : 1342
   Posted 2/6/2009 1:24 AM (GMT -6)   
That happened to me as well. The last big reaction I had was kind of in the shape of a diamond, and about as big as the palm of a hand. The itchy welt lasted for quite awhile, and left the skin discolored for even longer. I discovered that by letting the pen warm up longer (usually by holding it in my hand), that the shot is less painful and the reaction much smaller. I now get a small red spot no bigger than a nickel, and the itching and discoloration go away within a day or so.

Some people premedicate with prednisone for 2 days before the injections (I'm thinking it's 20MG each day). I also remember someone saying their doctor told them to premedicate with an antacid (something like Tagamat or Pepcid) and that for some bizarre reason, it kept them from having a reaction.
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