Chronicallyill, it depends on who you ask. My GI took me off of 6-mp because I'm also taking Humira and he said new research was showing you shouldn't be on 6-mp, methotrexate, etc. along with a TNF blocker. My rheumy, on the other hand, suggested me taking methotrexate along with my Humira because my arthritis is really flaring right now. To make both happy, we settled on trying sulfasalazine with the Humira first and then, if that doesn't work, trying methotrexate.
I've been on Remicade, Cimzia and Humira and can say that none of them have helped my arthritis enough. Some arthritis meds we tried hurt my stomach or else they did nothing. Pain meds were the same, although I am taking Hydrocodone currently. My GI has recommended trying Tysabri, but I think I'm too scared for that at this point. I'm sorry to hear that so many others are in the same boat as me, because I know how bad of a boat that is!