Another concern for those considering Remicade or Humira

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Ides
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Date Joined Nov 2003
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   Posted 2/19/2009 5:14 PM (GMT -7)   
A study was done in Germany among rheumatoid arthritis patients taking Remicade, Humira, Kineret and Enbrel. It found a substantial increase in the number of patients developing shingles in those taking Remicade, Humira, and Kineret. Enbrel apparently did not cause an increase in shingles.
 
"It's pretty clear that if you have had previous zoster [shingles] and take these anti-TNF monoclonal antibodies, you are going to reactivate it..."
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


isergodur
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Date Joined Jan 2009
Total Posts : 831
   Posted 2/19/2009 5:28 PM (GMT -7)   
what is Shingles?
24 year old female
Diagonsed with Crohns disease in December 2008..
Medication - Asacol, Remicade, Entocort


Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 2/19/2009 5:37 PM (GMT -7)   
I've never had chicken pox, and I think I'm about to start Humira.

I wonder if this new inactivated vaccine for shingles would also work for chicken pox?
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: 25mg Methotrexate. 8mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


gachrons
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Date Joined Mar 2007
Total Posts : 4527
   Posted 2/19/2009 5:40 PM (GMT -7)   
Thanks for the heads up. lol gail
Hallarious woman over 50 ,CD ,IBS 27 years--resection,fistula's,obstructions,hemmies,and still alive.lol gail


spookyh
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Date Joined Oct 2008
Total Posts : 1342
   Posted 2/19/2009 8:37 PM (GMT -7)   
I wonder if the shingles vaccine is allowed if you're already on Humira? I'm seeing my new GI tomorrow, so I'll have to ask.

I have noticed a few people on this board saying they got shingles while on a biologic. I'm not surprised to hear about the connection.

Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 2/19/2009 8:45 PM (GMT -7)   
You are not, however the article mentions an inactivated version as well...
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: 25mg Methotrexate. 8mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


RxCrohnie
Regular Member


Date Joined Sep 2006
Total Posts : 146
   Posted 2/19/2009 8:51 PM (GMT -7)   
I was on Humira and got shingles March 2008. I will probably be rechallenged with humira again next week. The Immunoloy group at Duke University looked at my case when I was hospitalized there in January. They said that it is is not likely that I will get shingles again. I cannot have the shingles vaccine because I am on Prednisone and pred lowers your immune system giving a risk for actually getting the shingles itself. The last packaged insert I read on Humira for primary shingle risk was 4% but I am sure that it is increased now. I will say this, you as an individual have to outweigh the risk of getting shingles vs the benefit of the biologic theragy.
35 yo--Crohns since 2000, Granuloma cysts in mouth-oral surgery X2 in 2000, Fistula colon 2006, Rectovaginal Fistula 2008, 2 Ulcers Rectum, Joint pain. Kidney Stones. Dx with Migraines in 2002 and Ovarian Cysts with Endometrosis 2001.  Dx with Fibromyalgia in 2007 and IC in 2008.  Now receiving Cimzia, Topamax 300mg daily, Cymbalta 60mg daily, Prevacid 30mg, Maxalt, Vicodin as needed, Fish Oil, and Multivits   
 
RxCrohnie 


Aimee =)
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Date Joined Jun 2004
Total Posts : 1020
   Posted 2/19/2009 9:35 PM (GMT -7)   

Since shingles is often triggered by a weak immune system, it makes sense that Humira and Remicade use might bring it on.

My dad had shingles a couple of years ago and while painful, it wasn't life threatning and he healed within a week.

Humira saved me from surgery and gave me my life back so shingles isn't a risk worth giving that up. That said, I may ask my GI next time I see him if he recommends the shingles vaccine.

BTW - I was on Remicade 2.5 years and have been on Humira for 2 years.


spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 2/20/2009 8:29 AM (GMT -7)   
I read a study awhile back that watched several groups of seniors citizens. Those in the group that got the vaccine AND did tai chi everyday had the least incidence of getting shingles. Plus, those that got it anyway had only a mild case. Guess we should all take up tai chi :).

sosueme
Regular Member


Date Joined Mar 2007
Total Posts : 53
   Posted 2/20/2009 12:03 PM (GMT -7)   
I have been on remicade 5 1/2 yrs. now and have had shingles twice in that time. First time i was not sure what this patch of itchy red dots were and when I went for my remicade infusion mentioned it to the nurse, who in turn got the dr. to come in and look , he said shingles and no remicade, it had already been mixed so insurance I assume payed for a dose i did'nt get. When it happened again the shingles I mean, I had to go to out patients , saw Dr. and got the right meds to clear everything up. I really don't remember how long that took thou.
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