Severe joint pain

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Pigdoc
New Member


Date Joined Dec 2008
Total Posts : 19
   Posted 2/26/2009 8:18 PM (GMT -7)   
I've been on Imuran since Jan 6, 2009, and it appears to be slowly helping my Crohn's. Blood tests get better every two weeks, and the GI doc has slowly decreased my Prednisone down to 30mg a day (it was 80 after my flare up in December). But two days ago, I started having pain in my knees in the evening. It worsened over the night, finally becoming so unbearable that I had to go to ER at 5am. The pain was in both knees, some bit also in ankles, and tylenol did not touch it. I seem to remember that a possible side effect of Imuran is joint pain. Is this correct? At the ER, blood tests showed me to be low in Magnesium, otherwise normal (for my Crohn's state). After some pain meds, they sent me home and today went as normal. Has anyone else had this occur? Thanks in advance.
Pigdoc

currently: pred 30mg/d, Pentasa (1000mg/d), Imuran (4.5 pills/d), immodium (1/d), iron pill (3/d), Lantasa (42units/d), Humalog (as blood test dictates, about 4 units/d)
CD for 20+ years
Px now: Pentasa 2000mg/d, prednisone 80mg/d, Imuran 210mg/d, salagen
Also, immodium 1x/d


Pigdoc
New Member


Date Joined Dec 2008
Total Posts : 19
   Posted 2/26/2009 8:29 PM (GMT -7)   
Added info:
Level of Imuran is 225mg/day. I've also had noticeable hair loss, is this often seen with Imuran also?
CD for 20+ years
Px now: Pentasa 2000mg/d, prednisone 80mg/d, Imuran 210mg/d, salagen
Also, immodium 1x/d


mtgman
Veteran Member


Date Joined Mar 2005
Total Posts : 1289
   Posted 2/26/2009 8:43 PM (GMT -7)   
i'm not on imuran, but i have joint /muscle pain on and off....sometimes really bad...never bad enough to go to the hospital though...could be the prednisone also i think...i'm at 40 right now tapering from 60

Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 2/26/2009 9:41 PM (GMT -7)   
Yes, Imuran can most definitely cause joint pain. I do not know your height and weight, but 225 mg is a rather large dosage. If I recall correctly, Imuran for CD is usually prescribed at 1.5 - 2.5 mg per kilogram per day. Others here have had intolerable joint pain with Imuran. Some have done well when switched to 6MP.

Imuran is a folic acid antagonist. If you have not had B 12 and folate levels done recently, ask the doctor to run them. Taking folic acid can mask a low B12 problem so don't supplement with it until levels are known. My doctor prescribed 1 mg of folic acid daily and my Imuran hair loss stopped.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


Pigdoc
New Member


Date Joined Dec 2008
Total Posts : 19
   Posted 2/27/2009 6:10 AM (GMT -7)   
Thanks for the response. As to weight, I'm down to 185, still heavy for 5'10", but not huge. I'll check into the folic acid and B12 areas.
CD for 20+ years
Px now: Pentasa 2000mg/d, prednisone 80mg/d, Imuran 210mg/d, salagen
Also, immodium 1x/d

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