New Drug anyone tried it?? Looks promising.

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redspot321
Regular Member


Date Joined Jan 2006
Total Posts : 303
   Posted 3/4/2009 6:29 PM (GMT -7)   
Ustekinumab - Used to treat  psoriasis. It not a TNF blocker but a IL-12 blocker whatever that is. It is still an immunosuperssive but treatment is only 7 injections a year.
 
The University of Miami has a Clinical trial for Crohns right not. I would go but Im afraid of being placed in the placebo group........
 
This drug is available in canada and Europe
 
 
WHAT DO YOU THINK??
 
TNF blocker VS IL 12 blocker?
30yo male
Currently on LDN for Crohn's with good results
 
63cm resection in '08, exausted all meds except pred :)
Avascular necrosis of both hips, Degenerative Disk disease with 5 herniated disk, Asthma, etc etc....


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 3/4/2009 7:07 PM (GMT -7)   
It's been discussed here a few times I think. It does sound promising.
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira. 25mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


redspot321
Regular Member


Date Joined Jan 2006
Total Posts : 303
   Posted 3/4/2009 7:55 PM (GMT -7)   
I think Ill enroll in the U of M trial! Im just wondering if these are worse than the TNF blockers?
30yo male
Currently on LDN for Crohn's with good results
 
63cm resection in '08, exausted all meds except pred :)
Avascular necrosis of both hips, Degenerative Disk disease with 5 herniated disk, Asthma, etc etc....


Bane
Veteran Member


Date Joined May 2007
Total Posts : 589
   Posted 3/5/2009 12:33 AM (GMT -7)   
i hate getting put in placebo groups... but most studies like this pay a nice chunk of cash, so w/e. if i get randomized to placebo, its nothing i havent dealt with before.... except now theres a reward at the end :D
21, Male, diagnosed over Christmas Break of my Junior year in High School. BEST CHRISTMAS EVAR LOL

(not really)


dietcoke
Regular Member


Date Joined Jul 2008
Total Posts : 186
   Posted 3/5/2009 2:00 PM (GMT -7)   
There's a clinical trial being done at Mass General Hospital in Boston too.
39 years old female, Dx'd 2000 Crohn's Colitis in entire colon
Hypersensitive/Allergic to Asacol/Pentasa/Budonside/6MP/Immuran and more
Past meds that worked: Cipro, Prednisone
Just stopped Humira 1/1/09 (Didn't work - bad side effects too.)
Started Remicade 1/15/09 ... and waiting for it to work

Daily: Folic Acid, Vitamin C, Fergon Iron Supplement, Omega 3, Multi-Vitamin


Kaycie
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Date Joined Jan 2006
Total Posts : 449
   Posted 3/5/2009 4:38 PM (GMT -7)   
This drug is also referred to as ABT-874 - IL 12. It is in clinical trial at Barnes Jewish in St. Louis. I was in it and had very minimal relief. The thing about it is though it is a different type of drug, it is still along the same lines of a TNF blocker, just a stage before. If you have failed Remicade, Humira, or Cimzia, it is actually along the same lines. As much as I hate Tsyabri, it is a completely different drug make-up, so therefore would be more effective.

FWIW, I hardly ever have reactions to drugs, but with ABT-874 - IL 12 - I broke out in skin lesions.
Kaycie - Age: 26
Crohn's - Dx Nov 05
Failed Remicade, moving onto a Clinical Trial called ABT-874 - Tentative start date - 10/2/08 - 10/16/08  - Infusion, every 4 weeks.
IVF #1 (In-Vitro Fertilization) - Failed
IVF #2 - IVIg, Heparin, Baby Aspirin - TWIN GIRLS!!!
Reagan Dawn - 8/2/07 - Lived 1 hour 27 minutes due to Cloaca, NOT affiliated with my Crohn's
Addison Maria - 8/2/07 - 13 months old


Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1445
   Posted 3/5/2009 7:59 PM (GMT -7)   
Kaycie, I think ABT is a different drug from Ustekinumab. I know it's hard to keep them all straight!

http://www.medscape.com/viewarticle/582678
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira. 25mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


Bane
Veteran Member


Date Joined May 2007
Total Posts : 589
   Posted 3/5/2009 9:18 PM (GMT -7)   
If it is ABT-874, im in a study for that at Mayo. havent had any problems with it, and its put me into remission with the help of a good diet.
21, Male, diagnosed over Christmas Break of my Junior year in High School. BEST CHRISTMAS EVAR LOL

(not really)

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