Spifficial, yes, you can lose response to Remicade while taking it. I had good results on it for a year or so, then started losing response. We increased the frequency of the doses, which maybe helped for a while, and then I started losing response again. Then, I started having allergic reactions to it and had to stop anyway. I'm opposite of most people in that I took Cimzia before Humira (by being in a clinical trial for Cimzia). When the trial ended, we decided to try Humira instead to see if it helped more with the arthritis, but I don't know that Humira works any better than the Cimzia in that regard. Both Cimzia and Humira have kept my Crohn's in remission.