Imuran experts?

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73monte
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Date Joined Mar 2007
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   Posted 3/6/2009 7:53 PM (GMT -7)   
I have a few questions about Imuran, as my daughter is into her second week, and currently on 50mgs per day.
 
So far no serious side effects, but she has a bit of a skin rash, on her buttocks of all places. This may be something totally unrelated mind you. It's a small area on both sides, and there's no pain or discomfort. Is this a likely side effect, and of any concern? 
 
I'm also wondering about the other things that she's taking along with Imuran, and would like to know if there are any interactions. She is taking Pentasa, and an iron supplement at the same time as the Imuran, at about 9pm each night.
 
Thanks, Tom.
My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Has used Prednisone and Pentasa. Started Imuran (02/09), had an abdominal abscess (12/08). 2cm of Stricture.


Ides
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Date Joined Nov 2003
Total Posts : 7077
   Posted 3/6/2009 8:52 PM (GMT -7)   
When you say a "bit of a skin rash" I am assuming that it is a very small area of inflamed skin. Are there pustules or blebs on the skin or merely red, raised bumps? My first inclination, without pulling my lists of side effects, is to tell you that this likely not associated with her medication. Under garments made from synthetic materials are HUGE culprits in the broken out butt syndrome. Back in the 70s when all uniforms were made of nylon, I fought a never ending battle with butt blebs. The material simply did not breathe and me skin reacted.

There is some discussion about concurrent use of mesalamine products and Imuran - "Use with Aminosalicylates: There is in vitro evidence that aminosalicylate derivatives (e.g., sulphasalazine, mesalazine, or olsalazine) inhibit the TPMT enzyme. Concomitant use of these agents with IMURAN should be done with caution."

Here is a program that lets you check for interactions between medications: Drug Digest Interaction Checker
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 

Post Edited (Ides) : 3/6/2009 8:55:32 PM (GMT-7)


Rider Fan
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Date Joined May 2008
Total Posts : 1445
   Posted 3/6/2009 9:03 PM (GMT -7)   
Wow, I never knew that about Aminosalicylates and Imuran Ides, interesting.
32 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira. 25mg prednisone. Udo's Choice Probiotics (30 billion).

Tried SCD, didn't work, now avoiding gluten and dairy.


catpower
Regular Member


Date Joined Nov 2008
Total Posts : 192
   Posted 3/6/2009 9:41 PM (GMT -7)   
My GI took me off of Asacol when I started Imuran b/c he said some people do have reactions from the combination and he didn't want to risk it.

As for the rash, I've only been on Imuran for about 2 weeks, but so far no rashes! However, when I have a lot of cold sweats during the day or night, sometimes I get a rash there.
Diagnosed with Crohn's Disease; Meds: Entocort & Asacol; female in late 20s.


73monte
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Date Joined Mar 2007
Total Posts : 1494
   Posted 3/7/2009 8:33 PM (GMT -7)   
I believe they want to keep her on Pentasa until the Imuran has a chance to reach it's full effectiveness. Likely about 3 months. I don't really think that Pentasa worked for my daughter, as when last hospitalized, she had severe inflammation going on, while taking Pentasa. 
 
Tom.
My daughter was diagnosed Feb. 19/07, (13 yrs. old at time of diagnosis), with Crohn's of the Terminal Illium. Has used Prednisone and Pentasa. Started Imuran (02/09), had an abdominal abscess (12/08). 2cm of Stricture.


Celey
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Date Joined May 2007
Total Posts : 1284
   Posted 3/8/2009 11:13 AM (GMT -7)   
Huh... I didn't know about that, either... I take Asacol (pretty much Generic pentasa) and Imuran, too... But... my GI doctor is well-aware of what I'm on... And he hasn't said anything about changing it... so.... *Shrugs*
I think I am being picked on by life, sometimes. But's that okay. Life and I are good buddies... I know life doesn't mean no harm. It just is the way it is. I can accept that.


Jper
New Member


Date Joined Jul 2011
Total Posts : 6
   Posted 7/9/2011 8:10 AM (GMT -7)   
I've had a complete body rash for a week now. Checked into the emergency in the hospital last Tuesday and the doctors can't figure it out. I stopped taking imuran immediately but feel trapped. Luckily I have my iPhone and Internet so I can try to figure this out. What can I do to make this go away? Doctors seem to think I'll infect someone and basically locked me up in isolation. Please help!!!

dt19&99
Regular Member


Date Joined Apr 2009
Total Posts : 174
   Posted 7/9/2011 8:26 AM (GMT -7)   
I've been on Pentasa and Imuran for about a year and haven't had any side effects as of yet

Jper
New Member


Date Joined Jul 2011
Total Posts : 6
   Posted 7/9/2011 8:48 AM (GMT -7)   
I'm very happy for you, it's not something I wish upon anyone. I got these problems after 4 months of taking Imuran. I started because my old Crohns meds weren't working and I guy I work with has been on it for 4 years and zero problems. Bad decision for me I guess.
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