does Humira make you feel "wired"?

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ivy6
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Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 12:32 PM (GMT -7)   
I can never predict what Humira will do to me. Sometimes it has a sedative effect, and at other times, like tonight, it makes me feel completely "wired" and sleepless. The "wired" effect seems to get worse the later I inject at night.

Does anybody else have this?

Ivy, wired and up since 3.30 am... redface
Co-Moderator Crohn's Forum.


LMills
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Date Joined Apr 2008
Total Posts : 1753
   Posted 3/12/2009 1:23 PM (GMT -7)   
I am just tired all the time haha. The only thing that has have ever made me feel wired is the prednisone. Are you taking anything else? Although, I'll admit I wish the humira had that effect on me! Hope you're getting enough sleep though...
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 5 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and good probiotics.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Attempting a diet without refined sugars, high fat content, bleached or bromated flour, most dairy, red meat, and avoiding anything spicy like the plague. Also refuse to eat anything with trans fat or high fructose/corn syrup.
"He who has a why to live for can bear with almost any how."


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 1:28 PM (GMT -7)   
Erm, well, I got to bed at 11.30 and was awake, buzzing, at 3.30... so no, not enough sleep :-) LOL.

Like most people here, I take a ridiculous amount of medication, but I'm pretty sure it is the Humira doing this. On the odd occasion that the Humira does make me wired, it usually only lasts 12 - 36 hours, and then the terrible fatigue returns.

In the mean-time, I've done the dishes, stripped the bed and put on a load of washing, and it's not even 7.30 am!!! I'm NEVER able to functionn this early in the morning, LOL. Oh well, I should make the most of it, shouldn't I?

How are you, LMills?

Ivy.
Co-Moderator Crohn's Forum.


LMills
Veteran Member


Date Joined Apr 2008
Total Posts : 1753
   Posted 3/12/2009 1:33 PM (GMT -7)   
Hey, as long as you're getting stuff done when you're hyper hah...That's the one thing I appreciate about prednisone's side effects. I just hope you'll be all right :)

I'm okay. Have been through more than I ever bargained for this past week. I will probably write a new post/rant in a moment because I don't know what to think...but I'm sitting here with my fiance still...that's all I need at the moment.
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 5 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and good probiotics.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Attempting a diet without refined sugars, high fat content, bleached or bromated flour, most dairy, red meat, and avoiding anything spicy like the plague. Also refuse to eat anything with trans fat or high fructose/corn syrup.
"He who has a why to live for can bear with almost any how."


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/12/2009 4:34 PM (GMT -7)   
For me, it was more noticeably with Remicade and the Cimzia (my current med). I'm not sure but my own personal hypotheses (for me), are that
1. altered brain chemistry . I don't get headaches near as much since I started the biologics. Actually I start to get more headaches, the more out of control the inflammation is.

2. My body is used to the fatigue. When the inflammation starts to get under control and especially that fast, I get kinda wired. Again, brain chemistry, but through different routes (starting at the periphery and then working inwards in a kinda cascade). There is also less pain and swelling in the joints so I AM able to do more.

No real proof behind this, but JMHO.
"The earth laughs in flowers"


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 4:37 PM (GMT -7)   
... in the same way that we can get really moody and irritable before a sudden onset of severe symptoms?

I've always felt, like you, that altered brain chemistry has something to do with that.

I.
Co-Moderator Crohn's Forum.


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/12/2009 4:52 PM (GMT -7)   
Yuppers...again JMHO...it seems that my headaches are tied to this DD. So it would stand to reason that I have some inflammatory proteins (marker, antibodies, cells: part of the whole inflammatory cascade) in my nervous system. Then I get a bit rush of the biologics (esp when administered IV), which start attacking right away and stops the cascade quickly. My brain interprets this as "wired". It's been awhile since immunology...and no real scientific proof to stand behind. Just my own experience...(oh, and I had a blood patch to fix a CSF leak caused by a lumbar puncture. so I do have some blood cells in my CSF)

Ivy, do you get headaches as well? and if so, do you think they are caused by this DD?
"The earth laughs in flowers"


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 4:58 PM (GMT -7)   
Yes, I do, but I have fibromyalgia. I attribute the headaches to that fun illness rather than the Crohn's... but could be wrong :-).
Co-Moderator Crohn's Forum.


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 4:58 PM (GMT -7)   
ps. That may only be a homemade theory, but it makes a lot of sense to me. Thanks.
Co-Moderator Crohn's Forum.


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/12/2009 5:10 PM (GMT -7)   
I read that fibromyalgia may also be due to immune dysfunction. As to the cause of dysfuction (environmental, pathogen, genetics) I think is still hotly debated on both issues.

I also find that I feel worse with immunizations (I've had soo many including rabies, yellow fever, typhoid, just to name the exotics). I feel that they work...but maybe I shouldn't get anymore. Had real bad days after my shots for the flue and booster for pneumonia. (it was about 3 days after) and I couldn't seem to get better.

There is still so much science doesn't know about immunology. Heck what they do know would probably barely fill a thimble in the sea of possible knowledge about just this one subject. And don't even get me started on brain bio...we're still in the dark ages on that one...
"The earth laughs in flowers"


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 3/12/2009 5:15 PM (GMT -7)   
While we're on the subject of immunology, I would dearly love to know why we aren't referred to see an immunologist as well as (or even instead of) a gastro. I suspect we might get more intelligent and holistic care with an immunologist, as I find that many gastros don't want to "see" the extra-intestinal manifestations of our disease... let alone any other hidden illnesses that we might have.

Ivy.
Co-Moderator Crohn's Forum.

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