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LondonRed
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Date Joined Oct 2007
Total Posts : 1184
   Posted 3/13/2009 1:04 PM (GMT -7)   
Otherwise known as Non Steroidal Anti Inflammatories. e.g. Asprin.
 
Now I am told that Asacol is like an Asprin but for the Colon....
 
I have been having stomach ulcers (twice now) in the 18 months I have been taking Asacol. Does anyone else have a problem with anti-inflammotories and does this mean I have go the natural route?

Diagnosis Oct 07 and then Aug 08: Inditerminate Colitis currently under some. Current Medication: 500mg Asacol Suppositories, 800mg Asacol Tablets x 2 a day.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/13/2009 1:29 PM (GMT -7)   
Asacol is not a NSAID though. I take Asacol and never had in kind of stomach ulcer or problems like that. Many people with Crohns also have GERD related to their Crohns. So maybe that is what is going on with you. I have to take Prilosec daily. Have you ever been tested for H Pylori? That might be something to check out too. Hope that helps.

Gail *Nanners*
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 3/13/2009 1:32 PM (GMT -7)   
Mesalamine is the medicinal component of Asacol and Pentasa. Mesalamine is thought to be the theraputic part of the sulfasalazine molecule. It is somewhat related to sulfa medications. Mesalamine is metabolized in the body to N-acetyl-5-aminosalicylic acid. Aspirin is acetylsalicylic acid. That is why you were likely told that Asacol is like aspirin.

People with CD or UC are usually told to avoid NSAIDs. The main reason is that NSAIDs are known to cause intestinal disturbances in people that don't have IBD, so the problem can compound IBD problems. Also, NSAIDs have been proven to cause ulcerations in the small bowel making it difficult to differentiate between Crohn's and NSAID ulceration.

Side effects of Asacol on the GI system [taken from the prescribing information]: "Gastrointestinal: Anorexia, pancreatitis, gastritis, increased appetite, cholecystitis, dry mouth, oral ulcers, perforated peptic ulcer (rare), bloody diarrhea. There have been rare reports of hepatotoxicity including, jaundice, cholestatic jaundice, hepatitis, and possible hepatocellular damage including liver necrosis and liver failure.

So Asacol could be causing your stomach problems. Have they done an upper endoscopy to biopsy the stomach ulcers? Crohn's itself can cause ulceration in the stomach. There are other medications to treat CD besides the mesalamine products. If your doctor decides that Asacol is the problem, he/she will have other things to offer.
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1184
   Posted 3/13/2009 2:30 PM (GMT -7)   
I just had an upper endoscopy as I did last summer. Last summer they just found and ulcer with no bacteria, this time they found H-Pylori and also Gastritis. I think the Asacol might be causing the stomach problems. Does anyone know an alternative to Asacol?

Diagnosis Oct 07 and then Aug 08: Inditerminate Colitis currently under some. Current Medication: 500mg Asacol Suppositories, 800mg Asacol Tablets x 2 a day.


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 7077
   Posted 3/13/2009 2:44 PM (GMT -7)   
Well, Asacol can't give you the bacteria that causes a stomach ulcer. It might be contributing to the gastritis. I'm not sure if the gastritis makes one more susceptible to H Pylori.

There are alternatives to Asacol. However, your physician would prescribe based on your medical history and the location and extent of your disease. If you want to see a list of other medications often prescribed for CD, check these out:
http://www.ccfa.org/frameviewer/?url=/media/pdf/FactSheets/aminosal.pdf
http://www.ccfa.org/media/pdf/FactSheets/biologics%20sept%202008.pdf
http://www.ccfa.org/frameviewer/?url=/media/pdf/FactSheets/immunomodulators.pdf
http://www.ccfa.org/frameviewer/?url=/media/pdf/FactSheets/steroids.pdf


Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.
 


LondonRed
Veteran Member


Date Joined Oct 2007
Total Posts : 1184
   Posted 3/13/2009 2:52 PM (GMT -7)   
Thanks so much that's helpful! If my stomach cannot take Asacol then I am not sure how I would treat the right side of my colon thats inflammed :(

Diagnosis Oct 07 and then Aug 08: Inditerminate Patchy Colitis. Also suffer from Peptic Ulcers could be related to Asacol. Current Medication: 500mg Asacol Suppositories, 800mg Asacol Tablets x 2 a day.


Jen77
Veteran Member


Date Joined Mar 2006
Total Posts : 2691
   Posted 3/13/2009 8:50 PM (GMT -7)   
I can handle Asacol fine, I think it's really helped me stay in remission. However I can't have any kind of NSAIDS. Before being diagnosed I used to take aspirin daily for work stress headaches. Between that and having Crohn's I ended up with a terribly deep ulcer at the end of my small intestine. Almost bled to death, they had to in and do an emergency colonoscopy to fix the ulcer.

So they are two very different things for me! One helps and one is a big no no!
~Jennifer
 
Diagnosed with Crohn's Disease 2/06, and Health Anxiety/OCD 12/08 Taking Asacol, Questran, Toprol XL, and Lexapro.


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 3/14/2009 7:11 AM (GMT -7)   
I agree with Jen77. Asacol and its sister med Pentasa are very mild meds. I personally don't think Asacol caused your ulcers. I think you got the H Pylori and that caused the ulcer. Generally they treat the H Pylori with specific antibiotics and meds such as Prilosec, Nexium, etc. Good luck!
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*
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