active disease

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Regular Member

Date Joined Oct 2006
Total Posts : 87
   Posted 3/13/2009 9:30 PM (GMT -6)   
I had another scope done this morning and he found active disease even though i have been on remicade for 2 years and now switched to humira.He thinks that the tnf blockers just don't do anything for me.I have to go next friday to meet with him to discuss our next plan of action!!What else is there I can't take the oral meds due to reactions and the tnf blockers aren't working.What else is there???
dx in oct 2006
entocort ec 9mg 1xday
remicade 10mg per kilo every 6-8 weeks
phenagren every 8 hours
dycyclomine 20mg 3xday
iron 325mg 2xday
calcium supplement
hydrocodone/apap 5mg/500mg 1-2 tabs every 4-6 hours
hydroxyzine 25 mg 1 tab every 4-6 hours
glycopyrrolate 2 mg every 8-12 hours

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 3/13/2009 9:38 PM (GMT -6)   
Methotrexate? That can be given by injection.

Do you live in the US? If so, there are some trials that you may be able to enter. Prochymal, especially, sounds promising.

I'm sorry you're so unwell.
Co-Moderator Crohn's Forum.

Regular Member

Date Joined Feb 2009
Total Posts : 57
   Posted 3/13/2009 9:42 PM (GMT -6)   
I'm sorry that the TNF blockers don't seem to work for you. There is Tysabri, which works as an α4-integrin blocker. However, there is a risk of getting a brain infection called PML. The manufacturers measure the risk at 0.1% chance.
Dx Crohn's Disease in 2001 at age 14. Lost 3 inches of colon and 7 inches of ileum in 2004 bowel resection.

CD returns in October 2008 at age 22.

Current meds: Pentasa: 3000 mg; Fibercon: 2 pills 3x; Imodium: 2 pills 3x

Ineffective Drugs: Imuran, Entocort, Remicade

Veteran Member

Date Joined Mar 2007
Total Posts : 4527
   Posted 3/13/2009 9:43 PM (GMT -6)   
Hi I know how disappointing it is to fail a med and your Dr. must have something in mind.. have you tried Imuran? At least you will be seeing him soon and hopefully others here will be able to help with other med suggestions.. How have you been feeling lately? lol gail
Hallarious woman over 50 ,CD ,IBS 27 years--resection,fistula's,obstructions,hemmies,and still gail

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 3/14/2009 9:18 AM (GMT -6)   
What about Cimzia? That is another one given by injection. As you said you have a hard time with oral meds, maybe that might be another suggestion. I can relate to having problems with oral meds, luckily I am maintained with only Asacol, but many oral meds and supplements upset my gut too.

Good luck and big hugs,
Gail *Nanners*
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*
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