Anyone with skin rashes from Humira or Remicade?

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Blossom
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Date Joined Mar 2008
Total Posts : 176
   Posted 3/19/2009 4:33 PM (GMT -7)   
Hi,
 
I'm wondering if any of you have (or had) skin rashes after being on Humira or Remicade.
 
Here's my story, and I'd love to hear yours too!
 
I've been on Humira (every other week) for about 3 months.  I recently noticed a rash on my chest---reddish, sometimes a bit itchy or irritated after a shower etc.  I've had it for a month, and it's not going away, nor is it getting worse.  My Dermatologist did a biopsy, and determined it's a rare inflammatory condition.  I did lots of Internet research, and my conclusion is that my lowered immune system due to the Humira is causing/contributing to the problem.
 
I'm interested to know if anyone with Crohn's who is on Humira or Remicade has also experienced rashes, and if your doctor diagnosed it, the cause, the treatment etc.
 
Thanks so much in advance for your input!!
54 year old female;
 
Have had Crohn's of terminal ileum for over 9 yrs, but finally accepted diagnosis when it was confirmed Feb. 2008.
 
Allergic/hypersensitivity to Pentasa, Entocort, and 6-MP.  Recently started Humira in December.


chroniemomx2
Veteran Member


Date Joined Apr 2005
Total Posts : 2346
   Posted 3/19/2009 6:35 PM (GMT -7)   
Very interesting! I used to always get rashes when I got out of the shower...and yes they were a bit itchy too. My gi suggested I take a zyrtec every night for some sinus issues. And since I have started taking that I haven't had another rash after my showers. I have never asked my gi about it though.

Blossom
Regular Member


Date Joined Mar 2008
Total Posts : 176
   Posted 3/19/2009 7:44 PM (GMT -7)   

Hi Crohniemomx2,

Thanks for your input!  Glad the Zyrtec worked for you.  (I currently take Zyrtec, and have for years.)

I just gave myself another Humira injection today, so it will be interesting to see if my rash gets worse (or better) over time. 


54 year old female;
 
Have had Crohn's of terminal ileum for over 9 yrs, but finally accepted diagnosis when it was confirmed Feb. 2008.
 
Allergic/hypersensitivity to Pentasa, Entocort, and 6-MP.  Recently started Humira in December.


spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 3/19/2009 10:50 PM (GMT -7)   
I suffered from eczema prior to Humira, so it's hard to say what causes any rashes I get. A few months after I started Humira, I started getting a very itchy rash behind my knees. It comes and goes though (right now it's gone *crosses fingers*).

hspenser
Veteran Member


Date Joined Dec 2005
Total Posts : 544
   Posted 3/20/2009 5:11 AM (GMT -7)   

Absolutley....with no rhyme or reason I will break out in hives...a day, two days up to three days after injection...not every injection but every now and then...maybe 4 out of ten times.  It seemed to taper off a bit when I went from two shots every other week to one shot every week.

I have developed several spots of "dry" skin that does not go away with the use of a moisturizer.  My derm dr said it might just be an age related thing (I am 52)...I do not think so.

doesn't matter that much any more...today is my last injection of Humira.....next up?  who knows?


dx IBS 1999   UC 2000   CD 2001
Tested BIOGEN TYSABRI (gave me 2 years of remission)
tried Naltrexone Jan. 19, 2007 Stopped the Naltrexone July 28th...started Humira Aug 31st, 2007...current dose one shot every week. Also nightly dose of mesalamine.
Surgery Nov 4th, 2008 removed 30 inches of small bowel.
 Crohns is currently active and has been since April of 2005
52 yrs old


cutie
Regular Member


Date Joined Jan 2009
Total Posts : 80
   Posted 3/20/2009 11:02 AM (GMT -7)   
I have seborrhia and my derm. said its because of my immune system. I have a wash and a couple of creams I have to use twice a day to keep from itching.
age 41,diagnosed with CD in 11/07, Rx Pentasa 4000mg and Remicade.


buster12052
New Member


Date Joined Apr 2009
Total Posts : 1
   Posted 4/4/2009 9:05 AM (GMT -7)   
I've been on Humira for six weeks, I now have a rash on my upper arm, and feel itchy all over (inside and out). I'm due to take my Humira today and feel nervous about it.I love Humira, my skin, nails, and fingers are sooooooooooo much better....If a rash is all I get, I'm okay with that. Would appreciate any feedback.

mick1
New Member


Date Joined Dec 2009
Total Posts : 4
   Posted 12/28/2009 2:23 PM (GMT -7)   
Hi i have been on humira now for three months has been great for the pain and stiffness due to Ankylosing spondolitis, but now get very hot and flushed often, and have bad itchy, stinging skin when over heated or outside in sun. Anyone got any advice on this or experienced this? I am 47 year old male and have been diagnosed for about 18 months although have suffered from it for many years. 

beca123
Regular Member


Date Joined Jan 2003
Total Posts : 224
   Posted 12/28/2009 6:16 PM (GMT -7)   
I havent had a visible rash but since I have started the Humira I have had the worst dry skin around my neck. It itches horribly. Lotion doesnt help and it itches worse after the shower. I just connected it to the winter I never thought about the Humira causeing it.
20 yr old female, dx'd in 02, struggled for a year with controlling this retarded disease. Finally got on Remicade(miracle drug for me-at the time) was in remission until summer of 09. Remicade stopped working, switched to Humira. Had my first surgery, half the colon and some of the small intestine removed. developed abscesses. it was messy. Currently on no Crohns meds, going to probably start the Humira again soon.
 
 
 


mick1
New Member


Date Joined Dec 2009
Total Posts : 4
   Posted 1/4/2010 10:40 PM (GMT -7)   
thank you and good luck

Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 1/5/2010 4:56 AM (GMT -7)   
No problems as of yet.Crossing my fingers.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications:Humira,  Asacol, FolicAcid,  Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Pepcid Complete, Questran,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


caroline_r
Regular Member


Date Joined Apr 2004
Total Posts : 94
   Posted 1/5/2010 1:10 PM (GMT -7)   
Hey there :)

I started taking Humira last year in February. I would usually either get the rash the day after receiving Humira - but it was on my arms and it would go away after a few hours, or I'd get it after being on the direct sun for like 2 minutes (literally) and it would get really hot, itchy and a little bit painful. It also got away after 2-3-4 hours and I'd put some lotion on it. However, I haven't had the rash for quite some time since it's winter.

Do you live somewhere where it's sunny? I had a rash on my chest like 10 years ago and it was also an allergic reaction to the sun that wouldn't go away and it actually had nothing to do with CD. Since Humira and sun don't really get alone it could be you just got more sensitive to the sun?

Hope I helped...
21 yr. old with crohn colitis. Diagnosed in March 2004. No surgeries so far.


mick1
New Member


Date Joined Dec 2009
Total Posts : 4
   Posted 1/5/2010 9:32 PM (GMT -7)   
 hi i live in new zealand very hot the sun is not my friend at the moment roll on winterturn

soppendeuff
Regular Member


Date Joined Jun 2008
Total Posts : 27
   Posted 1/9/2010 8:41 AM (GMT -7)   
I started Humira in mid-November. It's helped tremendously with the Crohn's but each injection site, from the pen or the syringe, causes what starts as a little rash a few days or weeks later. It then turns into a red somewhat itchy big blotch and then never really goes away. It seems as though I'll get to keep an ugly scar from each injection. My gastroenterologist doesn't seem to have a clue what's going on (or really seem to care). I was on Remicade for years and never had a problem. Anyone have any thoughts? Thanks.

Cheyenne01
New Member


Date Joined Apr 2009
Total Posts : 3
   Posted 1/10/2010 7:57 PM (GMT -7)   
I started Humira in May of 09, best med ever, really helped. In Nov. I developed little water blisters(red, itchy, and inflamed) all over my body. Went to my Derm. he did a byopsy and it turned out to be Pustular Psorisis, I have never had any kind of psorisis before. My Gastro said it was cause from the Humira and pulled me off the med. in Nov. put me on Imuran, and another drug to help clear up the psorisis. Well here we are in Jan I have been on Imuran for 2 months and my crohns is still doing really good, but I still have the pustular psorisis(BAD)and now my hair is falling out( I have Blond hair thats to my waist). It's been 2 months since my last Humira shot. I'm really getting down, and don't think it was from the Humira, I could be wrong though. I go to see a rhumy this week they said he deals with auto amuine.

mkl11
Regular Member


Date Joined Jul 2007
Total Posts : 494
   Posted 1/10/2010 11:34 PM (GMT -7)   
Hey Cheyenne--
I've had a very similar experience as you.

I started developing skin problems with Remicade--a bit of plaque psoriasis in my belly button and behind my ear, but it came and went. Note, I never had psoriasis prior to Remicade. The months I was between medicines I was skin rash free.

I began Humira in October 2008 and it's been great so far, but I think I am going to stop taking it. The psoriasis worsened on Humira and I saw a derm who gave me Tazorac/Cutivate. It helps but the problem areas of my ears/belly button have not gone away. I began developing bumps here and there over the past few months. Last month, I EXPLODED with awful rashes all over the place.

I had a large rash that did not look like psorasis extend across my stomach to my sides (it was a shingles like pattern, but no shingles). The plaque psoriasis spread to my genital area, and I'm now on Vecitcal for that. Shortly after, I developed very very painful blisters, which I don't think is pustular psoriasis or erthyma nodsum. They get larger, sorta break and then dry out...but they won't go away for months. I also noticed soem psorasis developing on my arms.

One of the bumps recently got very infected and I had to be put on antibiotics. I am seeing the dermatologist who specializes in Crohn's + skin issues in a month from now. Fortunately, with a lot of moisturizing, much of the other rash has dissipated, but the bumps presist.

In addition to these problems, I've had endless infections (sinus, eye, skin, uti) over the past four months. I think my body has had it with Humira and I'm anxious to talk to my GI on Feb 3 about this problem.

I have read research that TNF blockers CAN induce psoriasis in patients. In fact, I Just reread the Humira safety instructions and it even notes this in FAQ--you CAN develop psoriasis. No idea whether it persists after you discontinue the meds though.

Good luck witih the rhuemy, and I'll keep people here updated on what my doc/derm says.
21 y/o, diagnosed 6/2007

Symptoms currently under control with Humira and a wheat-free, processed food-free diet. Beginning to have symptoms of GERD...


caroline_r
Regular Member


Date Joined Apr 2004
Total Posts : 94
   Posted 1/11/2010 6:11 AM (GMT -7)   
Hey :)

about psoriasis...I don't have it on Humira but here's what I know. You can develop it while on Humira/Remicade and in most cases it goes away after taking the med but it takes time. On the other hand, if you have a gene for psoriasis (it's the same for Lupus) you will develop it and it will never go away. I'm really sorry if you're both out of luck and stuck with it for life :( hope that's not the case and that it will go away. Try to be patient and wait, everything's not lost yet.

Cheyenne01...you could be losing your hair due to Imuran. It happens a lot actually. It's happened to me too but I have a lot of hair and in the end it didn't affect me that much. It's not like I lost all of my hair. However, some people really do lose a lot of hair while on Imuran. The good thing is that it goes away after you stop taking it...

Hope I helped. Best of luck to both of you...
21 yr. old with crohn colitis. Diagnosed in March 2004. No surgeries so far.


LMFD296
Regular Member


Date Joined Dec 2009
Total Posts : 146
   Posted 12/10/2010 7:10 PM (GMT -7)   
I actually was going to make a thread but i found this one. I have been on remi for about a year with no issues and complete remission. about a month ago i went to the docs and she just happened to look at my back and said i had a really bad rash,i had no idea but my back had been itchy. its hasn't gone away,but doesn't seem to be getting worse, i do however notice it on my chest as well and it seems to spread a tinny bit. its dry and red looking. she suggested no hot showers, tried and hasn't done much, any input? i plan on calling my GI Monday.

TIA
22 Male DX at age 12 w/ UC
Remicade.maint phase. 8/13/10 suddenly flaring.
Prednisone 6mg (weaning)
zoloft 100mg for anxiety

NEVER FORGET 9/11/01 343 R.I.P.

silvergriz
Regular Member


Date Joined Nov 2010
Total Posts : 86
   Posted 12/10/2010 7:42 PM (GMT -7)   
My Gastro-Doc wants to put me on Humira because I now have 5-6 fistulas and a stricture in my small bowel. I've had crohns for 10years now and this is the 2nd Gastro-Doc I've went to, he is supposed to be a specialist. I now have pre-existing liver issues, but they have been in the normal range for over a year, and I'm wondering if I should start Humira, or pass on taking the injections. I'm pretty scared right now, because I'm afraid of possibly having liver failure with this or other complications. I sure would appreciate a reply!! Thanks--silvergran(SandyJ)

Endeavor08
Regular Member


Date Joined Dec 2010
Total Posts : 380
   Posted Yesterday 6:30 AM (GMT -7)   
Wow this was really helpful, at the beginning of the summer I developed a rash on my butt, they were red bumps everywhere that would scab over. My GI didn't know what it was and neither did the regular doctor and she couldn't take a biopsy because there now new ones. But at the time I was struggling with Remicade it waring off, we shorten the time inveral and doubled the dose and neither of those did the trick. So two months ago I switched to Humira and the rash has completely cleared up.

I don't have any problems with the injection site, or rash now. I would think that maybe some people are developing rashes at the injection site because we are putting something foreign under the skin that our body naturally doesn't want to be there thats why it hurts and reacts. And as the body gets use to the injections the reaction should decrease over time. I'm no expert though of course, just a thought.

Good luck to everyone!
Diagnosed Nov 2008
Brother also has Crohn's.
Currently on Humira and Prednisone (almost done) and LDN. Was on Remicade but it stopped working as well.
Three abscess surgeries, four hospital stays.
Finally have the right remedy and heading in a positive direction.
I'm 20 years old, and had to put college on hold multiple times, excited to start again in the fall 2011.

Karineb
Regular Member


Date Joined Nov 2005
Total Posts : 319
   Posted 12/13/2010 2:01 PM (GMT -7)   

I have been on Humira for a little over a year.  In September I started getting a really bad rash in my butt crack (they think it is inverse Psorisis), and I am still waiting to hear from my GI.  I am now cover in a rash, about 90% of my body and I am still trying to get in touch with my GI.  I am so uncomfortable.  I know it has to be from the huira.  It will be interesting where I go from here as I have tried a lot of drugs before this. 

 

I have never had skin issues in my life! 



FunGuy
Veteran Member


Date Joined Oct 2009
Total Posts : 1070
   Posted 12/13/2010 6:09 PM (GMT -7)   
I have always had dry skin especially in the spring and the fall. I recently noticed that my thighs are bright red especially after a shower. I don't know if it is because of the Remicade. My skin all over looks drier than usual but perhaps it is because I got glasses?

buffymoon
New Member


Date Joined Jun 2010
Total Posts : 14
   Posted 12/26/2010 1:21 PM (GMT -7)   
I am also very glad to have found this thread, I've been so upset about my beautiful 29 year old daughter confused She's been on Remicade about 5 month now. Things initially were great! then she got a rash ALL over, itchy,red, and GI doc recognized it right away; referred her to Derm who biopsied and diagnosed her with psoriais. I don't know the med she got put on for that; topical. Now her hair is falling out!! What else for her? She's my youngest child, and has 2 kids of her own. She seems to maintain a decent attitude thru all this, gratefully. Her GI doesn't want to stop the Remicade..... what to do???

rpsteve
New Member


Date Joined Dec 2010
Total Posts : 12
   Posted 12/26/2010 1:40 PM (GMT -7)   
As soon as I started Humira I developed rashes under both my eyes just above my cheeks. They were very prominent and were particulary bad in the summer time. People would always ask what was wrong or if I was sunburned. I was just recently in the hospital and the Drs. noticed the rash and asked how long I had had them. I told them when and the one DR got very excited thinking he had figured out my problem (he thought I had drugged induced lupus). The test for that came back negative though.
 
 
 
Diagnosed with Crohn's Colitis March 2nd of 2009. Currently on: IVIG, Prednisone, B12 injection, Probiotics, Fluconazole. Perianal Fistula and Abscess - surgery for those on April 10th, 2009. Medications I've been on: Colazal, Humira, Cimzia.

pmedic
Veteran Member


Date Joined Nov 2009
Total Posts : 1658
   Posted 12/26/2010 4:08 PM (GMT -7)   
When I was on Humira, I developed an itchy rash on my arms, legs and chest. My primary prescribed vistaril and it seemed to work well for me. I would occasionally get a breakout but after taking the vistaril again, it would subside.
Dx:Ulcerative Colitis March 2008
Dx: Crohns May 2008

No surgeries yet but I am desperately trying to keep my colon.

8 blood transfusions, SVT due to low H&H, Anxiety during new medication injections due to past reactions.

Been through MANY medications with terrible results.

Currently on Cimzia, Lialda, Ambien (prn), xanax(prn), Vitamin D3, Folic acid and Biotin.

Organic diet has made a big difference for me.

Learning how to love life and relax.
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