Some questions about Cimzia administration/effectiveness.....

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Julie1014
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Date Joined Oct 2005
Total Posts : 1245
   Posted 3/26/2009 9:32 AM (GMT -7)   
I am in the middle of being approved for Cimzia.  Looks like all is a go.  My questions are about the procedure for administration.  They said a home-health nurse will be coming to my home.
 
1.  How long is the nurse with you?
 
2.  Do they bring their own scale to weigh you to calculate the dosage?
 
3.  Is it always two injections at a time?
 
4.  Does the nurse have to stay with you after the injection, or do they just leave?
 
Also, do you find Cimzia is working better than Remicade if you made the switch?  Do you still have to pre-medicate? Do you have to wait a certain period of time from your last Remicade treatment to start Cimzia?
 
One thing I know for sure, I won't miss spending half a day in an infusion clinic, lol! 
 
Thank you so much for your time!  Blessings, Julie:-)
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


ZenaWP
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Date Joined Aug 2007
Total Posts : 884
   Posted 3/26/2009 10:22 AM (GMT -7)   

Julie, I took Cimzia for over a year on a clinical trial.  Here is my experience:

1. I received injections as part of a clinical trial and had to stay there for 30 minutes afterwards as part of their regulations.

2. Dosage wasn't based on weight in the clinical trial.  Everyone received the same amount.  Not sure how it's done now that the drug is on the market, but I thought it was a standard dosage still. 

3. I always received two injections at a time...I chose to have them in my legs, so one in each leg.

4. See #1.  They stayed with me.

5. Cimzia worked better for me than Remicade did (I lost response to Remicade).  Seems to work about the same as Humira.

6. I still premedicated because I got injection site reactions. 

7. I was told I needed to wait one month in between the two. 


Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


Julie1014
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Date Joined Oct 2005
Total Posts : 1245
   Posted 3/26/2009 12:15 PM (GMT -7)   
Zena, thank you SO MUCH for the reply. Are you unable to receive Cimzia anymore because you are done with the trial? If so, are you taking anything? I hope you are feeling well.....

Anyone else who would like to share their "in home" experience, please let me know! Blessings, Julie
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Bible
Regular Member


Date Joined Jul 2007
Total Posts : 188
   Posted 3/26/2009 2:22 PM (GMT -7)   
I will have my first injection on Tuesday at the Drs. office. Then, I was told after the first couple of injections, they will start coming to my house/work. I don't know anything about the med. I would love to hear all the details.

Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/26/2009 3:05 PM (GMT -7)   
Good luck to you, Bible!
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/27/2009 6:56 AM (GMT -7)   
Bumping:-)
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 3/27/2009 7:29 AM (GMT -7)   
1 & 4. They don't allow me to take the med out of the frig until the arrive. Then it's a half hour warm time, they reconsitute the med, half hour wait time, inject. The first time I was injected, the nurse waited about 15 minutes. From then on she just leaves after cleaning up from the shot. Entire process is 1 hr 15 min.

2. It's not a weight based med. It's the same for all - 2 200mg injections=400mg total.

3. One right after the other. I chose my legs also.

Remicade put me into remission for 2 years. Then I lost it. Humira wasn't worth doing (but my insurance declined weekly shots). The jury is still out on Cimzia for me. I've had all three loading doses but am also having fistula issues so those might take longer. ANyway I hope Cimzia works even close to as well as Remicade did!

Good luck!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 - now 2 months into it & it was the right decision
--currently taking budesonide suppositories, 3mg at night.  SLIPPING big time.  Started Cimzia first dose 2/10/09.  Dx Osteoporosis 10/08 started Forteo 1/27/09
--single mom to 11-yr-old girl


crohn's pt mom
Regular Member


Date Joined Nov 2008
Total Posts : 86
   Posted 3/27/2009 8:30 AM (GMT -7)   
Good Luck Julie - we are waiting for an answer any day as to whether my daughter gets the assistance.  Her insurance doesn't cover it and my insurance company indicates it's more than $1400 per month without any insurance.

Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/27/2009 8:35 AM (GMT -7)   
Thank you so much!! Blessings, Julie:-)
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Kriss
Regular Member


Date Joined Mar 2005
Total Posts : 357
   Posted 3/27/2009 10:38 AM (GMT -7)   
I have never taken Cimzia, but I was at the doctor's this morning for Remicade (my first!) and the RN was getting Cimzia ready for another patient and I asked her about it... she said that in their office they found that their patients don't have as much luck with it (meaning it doesn't work as well) as Remicade or Humira...
32 year old female... diagnosed with Crohn's/Colitis at age 16, then with Proctitis in 2005... right hemi-coloctomy April 2001 (removed 12 inches)... currently taking 100mg 6MP, Canasa, acidolpholus, Protonix, B12 injections once a month, tapering dose of 40mg Prednisone, Bentil and Percoset as needed... considering Remicade


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/27/2009 10:55 AM (GMT -7)   
Oh, Wonderful..... shakehead
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 3/27/2009 11:44 AM (GMT -7)   

Julie, the clinical trial I was on said that all of their participants saw a good response to it, so maybe it depends on who you ask...what their personal opinion about the drug is.  As for why I'm not still on it, I had the option to continue it once the trial ended, but I was still having a little difficulty with my arthritis, so I decided to try Humira just to see if it worked any better (once you start feeling good, you notice the little aches more!).  Also, on the trial, I was receiving Cimzia every 2 weeks, and I would feel worse a couple of days before my next injection was due.  Once the drug was available on the market, it was only approved for monthly use and I was just afraid that I wouldn't be happy only getting it once a month...and who knows, maybe that's why some people aren't seeing as good of a response now, since people are only getting it once a month, vs. biweekly on the trial.  

So, I am on Humira and I still have arthritis problems, but at least now I know that I can take another shot every 2 weeks, so it's a little easier to deal with the problem...knowing it won't last too much longer.  But, there have been some bad flares lately that have made me seriously consider trying Cimzia again, so who knows where I will end up.  Both drugs kept my Crohn's in remission, it's just the arthritis that won't give in.  Good luck, I hope it works wonders for you.  I know that I was very happy that year that I was on Cimzia, compared to Remicade...just thought maybe there were even better options out there.     


Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/27/2009 12:22 PM (GMT -7)   
Thank you, Zena! And, the best of luck to you!:-) Blessings, Julie
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/27/2009 1:32 PM (GMT -7)   
I think bi-weekly would be great. It seems that it just exponentially drops at about 3 weeks and a couple of days. Heck, I'm soooooo in need for my next shot right now (on Tuesday).
It has proven to be pretty effective for me (it has allowed me to come down to 5 mg of prednisone). I wonder how well it do at 2 wks. I did ask my doc about increasing the dose (or interval time). I really want to get off the steroids (been on them for over 2 years now).
"The earth laughs in flowers"

Post Edited (Becoming undone) : 3/27/2009 5:19:43 PM (GMT-6)


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/28/2009 2:14 AM (GMT -7)   
Becoming Undone, thank you so much for your post. I am also steroid dependent. I can't get below 10mg. I've been on Prednisone for 3 years. I'm really hoping the Cimzia will help me. Were you on Remicade before? Blessings, Julie
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/28/2009 7:52 AM (GMT -7)   
Yes...but it started losing its effetiveness. I went down to 7.5 mg of prednisone but eventually had to steadily increase. (at the end I was on 10mg/kg every 4 wks). I tried Humira...absolutely didn't work. Cimzia has promise. Down to 5mg woohoo....
I thought I was the only one. Most people on this forum are only on the steroids for a couple of months. Me, it's going on years. Believe me, I've tried coming down(on very slow taper), then things deteriorate(due to the disease not the steroids withdrawl, we've ruled that out), and I end up in the ER bleeding...and I'm back up to 60mgs...feeel wonderful for about 24 hours...then the roid rage and everything else kicks in...no good.
My sister, with RA is also steroid dependent. She has been on it for 5 years (at a lower dose of 2-5 mg).
I wish you nothing but the best...hope it works for you...do you take calcium?
"The earth laughs in flowers"


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/28/2009 9:39 AM (GMT -7)   
Becoming Undone, I'm sorry to hear you are steriod dependent, but at least I don't feel so all alone, lol! You are down to 5mg?! That's wonderful! I was also receiving Remicade 10mg/kg every 4 weeks, and it just seems to be losing it's effectiveness, and won't let me taper off of the Pred. Yes, I take a Calcium supplement as well as Vitamin D.

Have you had to pre-medicate before the Cimzia injection? How long have you been on Cimzia? Any injection site reactions?

I wish you all the best! Blessings, Julie:-)
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/28/2009 10:25 AM (GMT -7)   
no pre medication. Heck, I used to have to take a lot of benedryl the first 48 or so hours after Remicade. There were times were I felt stuffy in head and chest...and I know I was kinda reacting to it, though I never had any redness or swelling near the infusion site.

Cimzia...nothing...no real need of benedryl either. I've been on Cimzia since December.

I think I would have improved better, but in January I had the flu shot and in February, I had a pneumonia shot. Now, I am not saying shots, in general, are bad, but for me they are...my symptoms appear to get worse a few days after and it takes me weeks to recoup. I have also had many weird vaccinations and, for me, it has seemed to interfere with my health.

when do you start the Cimzia?
"The earth laughs in flowers"


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/28/2009 10:38 AM (GMT -7)   
I'm in the approval process right now and hope to start within two weeks.... It's already been 6 weeks since my last Remicade infusion, but for some reason my GI said I should get the Remicade out of my system before starting Cimzia. Did you have to wait a period of time also before starting Cimzia?
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 


Becoming undone
Veteran Member


Date Joined Jul 2007
Total Posts : 927
   Posted 3/28/2009 10:56 AM (GMT -7)   
nope...thank goodness...how are you doing with the wait?
"The earth laughs in flowers"


Julie1014
Veteran Member


Date Joined Oct 2005
Total Posts : 1245
   Posted 3/28/2009 11:59 AM (GMT -7)   
Terrible, but I haven't been doing well since my last few infusions, lol!:-)
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)
 
 
 
 
 

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