Proton pump inhibitors

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Veteran Member

Date Joined Feb 2009
Total Posts : 1810
   Posted 3/27/2009 3:25 AM (GMT -6)   
Does anyone have reflux with their colitis? What do you take for it? I have heard that drugs like nexium can actually contribute to some forms of colitis. Anyone else heard this? Thanks!
diagnosed 1/09 with colitis,54 yo, colazal, fish oil, synthroid, cymbalta

Veteran Member

Date Joined Apr 2008
Total Posts : 1753
   Posted 3/27/2009 3:34 AM (GMT -6)   
I hadn't heard that...I take omprazole and it works wonders. I do feel a lot better on it.
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 10 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and Align probiotics given to me by my GI.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Diet almost completely without refined sugars, wheat, flour, gluten, high lactose dairy, and/or junk food in general.
Learning how to live again.
"He who has a why to live for can bear with almost any how."

Elite Member

Date Joined Apr 2005
Total Posts : 14995
   Posted 3/27/2009 8:33 AM (GMT -6)   
Many of us with Crohns also suffer with GERD. I take Prilosec and it works great for me, doesn't affect my Crohns at all. I have never heard of it contributing to any forms of colitis.
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Regular Member

Date Joined Feb 2009
Total Posts : 82
   Posted 3/27/2009 9:37 AM (GMT -6)   
I take Aciphex as needed and it works well. I haven't had any issuse with any worsening of my Crohn's symptoms.

21 years old, Female.
Diagnosed with Ileocolitis and Perianal Crohn's November 2008.
Currently on 15 mg Prednisone, waiting to be approved for Humira.

Veteran Member

Date Joined Feb 2009
Total Posts : 1810
   Posted 3/27/2009 7:08 PM (GMT -6)   
Thanks, that is good to know. Certainly do not want to do anything to make things any worse.

diagnosed 1/09 with colitis,54 yo, colazal, fish oil, synthroid, cymbalta

New Member

Date Joined Mar 2009
Total Posts : 6
   Posted 3/29/2009 12:33 PM (GMT -6)   
When i was in hospital for an emergency resection, they gave me proton pump inhibitors (I had a near-blockage due to several very small strictures, and I guess that caused a backup of stomach acid or something). I can't imagine my GI would prescribe those to me if they could make things worse.
DX with Crohn's at 21 in '06
Resection of TI and Cecum/3 Strictureplasties in May '08
I've been on most entry-level meds out there: prednisone, AZA, pentasa, ciprofloxacin, metronidazole, etc etc etc... starting Remicade soon, after discovering an enteroenteric fistula.
Flock of Parrotts- my family blog.

Veteran Member

Date Joined Oct 2005
Total Posts : 1245
   Posted 3/29/2009 4:46 PM (GMT -6)   
My GI prescribes me Prevacid. I'd be lost without it. I tried going without it for one week, and it was horrible, lol! Blessings, Julie
Diagnosed with Crohn's March 2006, Fibromyalgia Nov. 2008, Anxiety Disorder since childhood
Asacol 3 times a day, Remicade 10mg/kg every 4 weeks, Prednisone 10 mg, Miralax,  Prevacid 30mg, Vit B12, Vitamin D, Slow-FE (Iron), Hydrocortisone enemas
Imuran stopped 9/8/08 (possible Pancreatitis)
Paxil 40mg daily (for Panic disorder)
Xanax .5mg three times a day, 1mg at bedtime (for anxiety attacks)

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 3/30/2009 12:35 AM (GMT -6)   
There is a drawback to proton pump inhibitors. They reduce the pH of your stomach acid to levels below what is needed for your digestive enzymes to work properly. This results in incompletely digested food entering the colon and can cause food allergies to develop if the partly digested proteins can pass through a compromised intestinal lining. That result is much less trouble than ongoing acid reflux, which causes immediate and long-term damage, but it is another source of stomach grief. It is also very difficult to stop taking the PPI's if you regularly take a maintenance dose since there is a rebound effect. If you stop taking them, the result is an immediate strong overproduction of acid. It is a bit like being hooked on heroin.

Veteran Member

Date Joined Jun 2008
Total Posts : 1058
   Posted 3/30/2009 6:30 PM (GMT -6)   
Forgot to say - suggest to your doctor that you might be better off with an H2 blocker. Those are the older variety of treatment for reflux and basically target the inflammation and not the acid production. If those work for you, you are much better off using them. Particularly for Crohn's, the chances of high gut permeability are up and so food allergy development is likely when taking Proton Pump Inhibitors.

Veteran Member

Date Joined Feb 2009
Total Posts : 1810
   Posted 3/30/2009 6:40 PM (GMT -6)   
Thank you, Keeper. I thought I had read similar things before. I don't take it often but it is hard getting off them too. I don't like this class of drugs and it seems to me they could promote problems with bacteria entering the system that do not need to be there.

diagnosed 1/09 with colitis,54 yo, colazal, fish oil, synthroid, cymbalta

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