I've been on both Remicade & Humira. Remicade I built antibodies too and have been on the Humira since fall of 2006. I am a moderate to severe CD case so I've always been required to do the weekly shots. Most likely because I am on the lowest dose of Imuran (my mainstay maintenance drug) because higher levels make me toxic. I've read several ppl on here which have been on Humira for several years and are still in (so called) remission. I have to believe it's based on each of our responses to our drug cocktails, absorbtion capacity, current activity levels of the CD along with stess & diet. I don't think we can say, oh, it's "what I ate last night" (I know, bad example) or a number of other rational(s) we try to apply to a flare. Some of the drugs take a long time to really work in the first place. If you feel the bi-weekly shots are failing you and you are doing everything you know of to keep your CD as stable as possible you may want to talk with your Dr. about going to weekly doses. Good Luck and I hope I've given you some insight.