Well, I havent had many issues with biopsies and my colonoscopies, but I have had, and currently am, experiencing issues where my GI did a colonoscopy, says it looked OK and wants me to taper entocort and maybe other maintenance meds, even though I am having symptoms. Also, food coming out whole should have provoked further questioning on his part. Maybe taking digestive enzymes might help alittle bit? Either way, I am currently in the process of switching GI's due to similar reasons. I would probably recommend it in your case too, or at least get a second opinion. As people told me on here, I will tell you, that if you don't trust your doctor with his decisions then switch. I haven't seen my new GI, but I am already a bit less stressed that i've made up my mind to fire my old GI. Hopefully someone with more experience with PICC lines and stuff will respond. Hang in there and use your 'gut' feeling with your pred dose, just don't forget the calcium supplements.