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tomboi
Regular Member


Date Joined Jan 2009
Total Posts : 21
   Posted 4/15/2009 7:43 AM (GMT -7)   
i've been on pentasa 4months.......it seems doesn't work much i still get a little flare every now n then.  But the main question is does pentasa had a side effect on loosing hair.  Cuz i saw it some where on the net and it seems my hair line got a little upward.....=P

njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 4/15/2009 5:02 PM (GMT -7)   
Especially while on Pentasa, it might be useful to take 400 mcg to 800 mcg of folic acid.
 
-grrrr...somebody inserted a link on "xxx" that sent it to an ad. i removed the link. - njmom
-extra grrrr....somebody is automatically inserting a link to ads from the four letter word that starts with h and ends with p. moderators, can something be done about this? i can't spell the word or a link will be inserted again.

Post Edited (njmom) : 4/18/2009 12:11:59 PM (GMT-6)


CrazyHarry
Veteran Member


Date Joined Mar 2006
Total Posts : 1034
   Posted 4/17/2009 1:27 PM (GMT -7)   
i went to a ccfa educational seminar last year. at two different talks, but two different docs, they independently said that 5-asa drugs are statistically no better than a placebo for crohn's patients although there is a clinical response for uc sufferers. 5-asa oral drugs include asacol, pentasa, colozal. they also include rowasa enemas. i took all this stuff for years and i never felt it helped but i took it anyway. i never felt a placebo effect, but that is real though and you cannot discount that. however, imho, if you have been on it for a few months now and you do not feel it is working, talk to your GI about this cos, imho again, you are quite possibly wasting your money and also potentially harming your body by taking drugs that are not working for you.
Crazy Harry

---------------------------------------------
Crohn's since 1993 (17 yrs old then)
surgery in July '05 - removal of 2 inches at ileum and 8 inches of sigmoid colon (had fistula into bladder)
Nov '05 developed colonic inertia; July '06 told i needed ostomy surgery
began maker's diet in August '06 - now feeling the best ever with no symptoms of colonic inertia and i kept my colon
med free as of 10/31/07


LMills
Veteran Member


Date Joined Apr 2008
Total Posts : 1753
   Posted 4/17/2009 7:36 PM (GMT -7)   
I had to be on mine for a while before it started working..as in a couple of months as well. Perhaps wait a little longer and see? But like Crazy Harry said, there is no point in taking it and paying for something that doesn't even help you.
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 10 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and Align probiotics given to me by my GI.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Diet almost completely without refined sugars, wheat, flour, gluten, high lactose dairy, and/or junk food in general.
Learning how to live again.
"He who has a why to live for can bear with almost any how."


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 4/18/2009 8:14 AM (GMT -7)   
Are you really sure its not working??? I take the sister med Asacol and it works great for me, and I do not have CD in the colon. And I respectfully disagree with Harry here, because these drugs do work for many. I stopped taking my Asacol at one time and immediately started flaring. Went right back on it and got better in no time. My Crohns is maintained solely with the Asacol and I am currently in remission. Oh and my hair does shed alot, not sure if its the disease or the med, but you could try adding Folic Acid into the mix, that helps the hairloss. Good luck!
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4219
   Posted 4/18/2009 8:16 AM (GMT -7)   
Pentasa helps me a TON. I would not go off of mine. I was losing hair as well. I eneded up taking biotin and folic acid and then my doc had me on rogaine for about 4 months. It was just long enough to stop the hair loss. Despite what the comercials say I didn't start losing again when I stopped taking it.
27 Year old married female law student (last year!!). Diagnosed w/ CD 4 years ago, IBS for over 10 years before that, which was probably the CD. I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid. For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn. I also have bad acid reflux and have been on PPI's since age 13. I have been through prilosec, prevacid, and nexium. Currently I am on Protonix in the morning and Zantac at night.  I take xanax prn for situational anxiety (aka no easy bathroom access). 


HM
Regular Member


Date Joined Sep 2008
Total Posts : 211
   Posted 4/18/2009 10:34 AM (GMT -7)   
I actually switched from asacol to pentasa in January. I think it does help...maybe give it a bit more time or perhaps you need a larger dose.

35/f   proud single mom of 2

Diagnosed with GERD/Acid Reflex 2002

Diagnosed with IBS 2007

Diagnosed with UC, then Crohn’s 2008

Current medications: Endcort 3mg 2X daily, Pentasa 2 500mg caps 2X daily, Prilosec 20 mg 2X daily (if needed), Probiotics, Calcuim/Mag/Vit.D. Flinstones multi with Iron and Vit. C 500mg daily


njmom
Veteran Member


Date Joined Apr 2006
Total Posts : 1884
   Posted 4/18/2009 11:09 AM (GMT -7)   

There is no conclusive evidence that Pentasa does or doesn't work for Crohn's. The following meta-analysis of 3 clinical trials suggests Pentasa at 4 g/day appears to be superior to placebo BUT this conclusion rests upon using the ridiculous CDAI. Also, the placebo results differed widely between the trials, so the true clinical significance of the improvement is impossible to assess. 

"The aim of this study was to perform a meta-analysis of the efficacy results from 3 placebo-controlled multicenter clinical trials of slow-release mesalamine (Pentasa) for the acute treatment of mild to moderate Crohn’s disease. Three trials fulfilled the selection criteria (double-blind, placebo-controlled, randomized studies in adult patients treated with Pentasa 4 g/day for active Crohn’s disease). The efficacy and safety was evaluated in these trials by using the Crohn’s Disease Activity Index (CDAI) as the primary efficacy variable...For the intent-to-treat patients in the Pentasa groups, the overall mean reduction of the CDAI from baseline to the final visit was −63 points. The corresponding CDAI change in the placebo groups was −45 points; the net difference was −18 points. Compared with placebo, the 4-g/day dose of Pentasa was associated with a statistically significant overall improvement in the CDAI from baseline to the final visit (P = 0.04). When the meta-analysis was restricted to protocol correct patients, the effect of Pentasa became more pronounced (overall mean reduction of −83 CDAI points; P = 0.02, compared with placebo). Contrary to the consistent effects with Pentasa, the trial-specific reductions of the CDAI with placebo differed significantly between the trials. The meta-analysis of 3 large, double-blind, randomized studies in the treatment of active Crohn’s disease confirms that Pentasa 4 g/day is superior to placebo in reducing the CDAI but the clinical significance of the magnitude of this difference is not clear."


janicea
Regular Member


Date Joined Feb 2009
Total Posts : 350
   Posted 4/19/2009 7:20 AM (GMT -7)   
even though I ended up being allergic to the 5-ASA compunds, they worked for me. I also have pyoderma gangrenosum and that clearly started healing from it. Of course, the allergy put a stop to the improvement, and went backwards -- but the 4 months leading up to that I could really see the improvement.

3 days ago (it took me a month to recover from the asacol) I started on Boswellia (frankencense extract) because it's been shown in a small study to be as or more effective. Bottom line is that I think I am already seeing results. Particularly in people with strictures, I think that the 5-ASAs and maybe Boswelia really really help.

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 4/19/2009 7:33 AM (GMT -7)   
I will say that despite what any studies say, the 5-ASA meds work well for ME. If I can get by with using the mildest forms of CD meds, I will continue to do so. My Crohns responds very well to them. And I am one of those folks janicea mentions that has the stricturing type of Crohns. JMHO
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 4/19/2009 7:35 AM (GMT -7)   
nymom the links are put in by the administrator. They are advertising links to earn funds to help keep Healingwell going.
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Spifficial
Regular Member


Date Joined Oct 2007
Total Posts : 33
   Posted 4/19/2009 10:31 AM (GMT -7)   
as for the hair loss: I too was losing my hair a lot more than usual (just after my 2nd surgery) and I was on Pentasa (plus a billion painkillers). My salon guru convinced me to use Avida shampoo and conditioner (i was using Pantine) and as soon as I did, my hair stopped falling out! She said it was something about all the meds I was on and the Avida took "impurities" out of the follicles. Bad news for the afghan rug i was going to crochet with all that extra hair from my hair brush, but good for my hair line :)

I use the Avida "Shampure" shampoo and conditioner, each bottle is about $10, but lasts me about 3-4 months. medium bottles.
Diagnosed CD in Dec 06', re-sectional Dec '07 and another April '08 (12" all together)
Currently on: Remicade , Mirena


jmiller056
Regular Member


Date Joined Feb 2009
Total Posts : 57
   Posted 5/5/2009 1:07 PM (GMT -7)   
After you started the Aveda, did the hair you lost grow back?  The right side of my head seems thinner than the rest and I'm trying to figure out if it is Crohn's, medication, or pattern baldness.  The thing is, I can only fine about 1 hair on my pillow, and after I wash my hair I might find 5, well below the 150 a day you are supposed to lose...  Thanks.
22 y/o Male; Dx Crohn's Disease in 2001 at age 14.
Lost 3 inches of colon and 7 inches of ileum in 2004 bowel resection.
CD returns in October 2008.
Current meds: Pentasa: 3000 mg; Fibercon: 2 pills 3x; Imodium: 2 pills 3x
Been on: Prednisone, Imuran, Entocort, Remicade

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