Starting CIMZIA this week - please share YOUR EXPERIENCES!

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BostonChronie
New Member


Date Joined Feb 2009
Total Posts : 12
   Posted 4/19/2009 9:00 AM (GMT -7)   
After recent allergic reactions to both Humira and Remicade, my GI is starting me on Cimzia this week. I am nervous about this drug because it is relatively new and I've yet to hear any solid information from my fellow Chronies.
 
Please share your experiences - both good and bad. I don't like the idea of being on this drug with the only knowledge I have coming from the manufacturer.
 
Thank you so much.

a/k/a Laurie. Living with Crohns since 1968. Too many surgeries to count. Total colectomy with ileostomy. Took Imuran for many years, but recent flares have required Humira Remicade. Cimzia.
 
Current meds: Tincture of Opium, Lomotil, Donnatol (as needed), Protonix, Celebrex, Cymbalta, Wellbutrin, Atenolol, Hyrdrocodone (as needed), B-12 injections, iron infusions.


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 4/19/2009 12:14 PM (GMT -7)   
I've had my loading doses and one maintenance treatment so far. I had an allergic reaction to Remicade (hives in the mouth) but not to Humira (it just didn't work). I don't seem to feel any side effects whatsoever from the Cimzia. The only thing is that I get bruises where the shots go in.


The shots themselves don't hurt, like Humira. That was a happy realization for me.

I think it's helping me. It's so hard to tell because so many other issues have complicated it. I've been on Cipro for 3.5 weeks and Flagyl along with it for 2 weeks. The combo was *really* hard on my gut and caused D that kept me up half the nights. Now I am off the antibiotics and hoping that I'll know the true effects of Cimzia within the coming couple of weeks.

If you're really nervous about an allergic reaction, maybe you could take Benadryl or some other antihistamine before the shots? Are you having the shots at home or at your doctor's office? I had mine at home and I decided to just premedicate like I did for Remicade and the Prochymal trial. Can't hurt to pop an antihistamine and buy yourself a piece of mind. Just a thought...

Good luck with it!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 not enough response
--currently taking budesonide suppositories, 3mg at night.  Started Cimzia first dose 2/10/09.  Dx Osteoporosis 10/08 started Forteo 1/27/09
--single mom to 11-yr-old girl


BostonChronie
New Member


Date Joined Feb 2009
Total Posts : 12
   Posted 4/19/2009 12:39 PM (GMT -7)   
Thank you for responding. I also got very bad brusing from the Humira, along with lumps that still haven't gone away after 4 months, and finally "scabs" at the injection site, which took 7 or 8 weeks to go away. The odd thing is that I did take Humira for several months over a year ago, with no local reaction, and it did make me feel better for awhile. I had to stop taking it because I developed an abdominal abcess.

What is Prochymal?
a/k/a Laurie. Living with Crohns since 1968. Too many surgeries to count. Total colectomy with ileostomy. Took Imuran for many years, but recent flares have required Humira Remicade. Cimzia.
 
Current meds: Tincture of Opium, Lomotil, Donnatol (as needed), Protonix, Celebrex, Cymbalta, Wellbutrin, Atenolol, Trazadone, Hyrdrocodone (as needed), B-12 injections, iron infusions.


patientspiders
Veteran Member


Date Joined Jul 2005
Total Posts : 733
   Posted 4/19/2009 2:18 PM (GMT -7)   
I'm about as far into my Cimzia as Sr, but I've been pretty lucky. I noticed an improvement pretty early on, and I am definitely much better than I was when I started back in February. My only trouble now is something referred to as "rebound constipation", which for me isn't the constipation so much as the gas and pain and bloating of my intestines actually healing and the normal balance of bacteria re-establishing. At least, that's my take on it after having a similar experience when the Remicade started working for me. So, I'm crossing my fingers and hoping this works as well for me as the Remicade. I hope it works for you too!

I don't bruise or have any real reaction from the shots themselves, either. They are a million times better than Humira.
27f, dx'd CD July '05 after 6 fistula/abscess surgeries
Remicade '05 through '08, with no other maintenance meds
Noticing a real difference with a Gluten-Free diet.
Currently on:
Cimzia (started 2-12-09)
Probiotics, Digestive Enzymes, Forvia vitamins, and calcium chewies
Prednisone free, again! WHOOPIE!


Benisone
Regular Member


Date Joined Jan 2009
Total Posts : 48
   Posted 4/19/2009 3:40 PM (GMT -7)   
I finished up my loading two weeks ago and my doctor wants me to be off the prednizone, hoping the cimzia will supercede the prednizone. Also I am on flagyl to cut down the bacteria growing in the fistulas, in which seems to help. I've notice healing time of acne, bruises takes longer, however that's not concerning me. What concerns me is that I want to be off the prednizone...

onthecan
Regular Member


Date Joined Mar 2009
Total Posts : 318
   Posted 4/19/2009 4:14 PM (GMT -7)   
 This Cimiza i have never heard of it but i also would love to learn more about it myself thanks. Thanks Jenn yeah
Had Crohns 17 years had numerous bowel resections,fistulas,fissures,hemmies,kidney problems,fibro,arthritis,dignosed at 13 had GI feeding tube,nasal feeding tube,cental lines,ports,4 ruptured bowel emergency surgeries,TMJ,depression,current meds are Hydromorphone,30 ,Hydromophome,8 ,Ketoprofen,100 ,Trazadone,50 ,Lorazepam,10 ,Zopliclone,5 ,atriplyine,75 ,Losac,50 Tylenol Athritis ,B-12 injections ,Iron injections ,Gravol,75 Predisone,5mg ,Humira,40mg once a week.Still looking for the doctor with all the answers if you find him forward him to me please.P.S my bathroom is the nicest room in my house cause i spend so much time there,i am thinking about installing the computer and maybe a hot-dog stand.


northernguy
Regular Member


Date Joined Oct 2007
Total Posts : 39
   Posted 4/19/2009 5:21 PM (GMT -7)   
Cimzia didn't work for me , but Remicade and Humira didn't either , so I guess i am anti- TNF treatment resistant. My doc just took me off of it early this month. I thought it hurt a bit when the nurse injected it because the injection takes awhile due to the consistency of the cimzia. It is like syrup! Hope it works for u though. I am on to the Tysabri soon.

ZenaWP
Veteran Member


Date Joined Aug 2007
Total Posts : 884
   Posted 4/22/2009 9:44 AM (GMT -7)   
Boston, there are several of us on here who either have been or are on Cimzia.  I took it for a year on a clinical trial before it was FDA approved.  I also had allergic reactions to Remicade, so I was scared when starting the Cimzia but had no reactions to it.  I got injection site whelps, but I get those on Humira also.  It stings, but not as bad as the Humira does.  It seems to work about the same as Humira does for me as far as my crohn's, but maybe a little better than the Humira with the arthritis.  The only thing that is different now is that Cimzia is given once a month...when I was on the trial, I received it every 2 weeks and even then, it wore off after about 1 1/2 weeks.  But, I have the same issue with Humira - it wears off about about a week and I can only get it every 2 weeks.  Cimizia seemed to be more consistent - it always helped and it seems that sometimes my Humira injection doesn't work as well as other times.  Best of luck to you.

Crohn's Disease, Acid Reflux/Gastritis, Hashimoto's Thyroiditis, Endometriosis, Arthritis, Depression/Anxiety.  Too many meds to list them all.  =) 


BostonChronie
New Member


Date Joined Feb 2009
Total Posts : 12
   Posted 4/22/2009 5:39 PM (GMT -7)   
Thank you for responding Zena. I have high hopes that this will work for me. The only thing left will be Prednisone, which for me, is the last resort. I'm a bit scared, but will go forward with it. My first injections will be next Tuesday. Let's just hope there's no reaction.
a/k/a Laurie. Living with Crohns since 1968. Too many surgeries to count. Total colectomy with ileostomy. Took Imuran for many years, but recent flares have required Humira Remicade. Cimzia.
 
Current meds: Tincture of Opium, Lomotil, Donnatol (as needed), Protonix, Celebrex, Cymbalta, Wellbutrin, Atenolol, Trazadone, Hyrdrocodone (as needed), B-12 injections, iron infusions.

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