Hi, my husband was on Remicade as well and was having treatments every 6 weeks as well for UC. At first he responded extremely well and was having them every 8 weeks; however after about 4 months or so, they just quit working and they had even bumped him up to 6 week treatments. The GI doc told us his body became immune to the derived antibody they use in Remicade. That's when they decided to switch him to Humira and he started it about 4 weeks ago. His 1st dose was 4 injections and then he just did another injection on the 15th. It doesn't seem to be helping him thus far, but does it take a while to kick in?? He gets really bad cramping afterwards? Does that happen for you all??? I know he has UC and not Chron's but I wasn't sure if it affected ya'll differently. Humira is our last hope before we have to consider a colectomy.