new med apriso

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heatmiser
Veteran Member


Date Joined May 2003
Total Posts : 1671
   Posted 4/22/2009 8:49 PM (GMT -7)   
Hi everyone,

I got something in the mail recently about a new 5-asa med called apriso. It's a once daily treatment. Just wondering if anyone here has tried it yet? I don't have good insurance coverage now so I won't be asking to switch at this point but I would love to only take meds once a day.

Jenn
Regular Member


Date Joined Oct 2004
Total Posts : 29
   Posted 4/22/2009 10:36 PM (GMT -7)   
Interesting, I'm gonna email my GI doc and ask about this. I'm currently only treating my crohn's with Asacol, so this may be something for me! Once a day is better than having to remeber it 3 times a day. Thank you for the heads up!

Bluize
Veteran Member


Date Joined Mar 2005
Total Posts : 635
   Posted 5/27/2009 3:00 PM (GMT -7)   

I have just been prescribed Apriso for Crohns.  My doc tells me to take 4 in the am and 4 in the pm.  Maybe it's different dosing for crohns vs UC also maybe it's in the beginning you take more and then go to a maintenance dose.

I'm bumping because I was searching and found this and it was exactly what my doc prescribed.  This drug has been around for a while in Europe but it just got approved in the US.

 


Susan
 
28 years with Crohns in the term ileum.  Feb 07 Resection.  No meds currently..but there will be some I'm sure. Taking acidophilus.


mbw1103
Regular Member


Date Joined Apr 2009
Total Posts : 71
   Posted 5/28/2009 5:02 PM (GMT -7)   

I just switched from Lialda to Apriso on Saturday. Biopsies from a recent colonoscopy showed inflammation in my small bowel.  I can't take steroids (bad reaction), so my doc suggested trying Apriso.  I was skeptical since it's the same active ingredient as other 5-ASAs (mesalamine), but was willing to try anything.  The big difference between Apriso and other 5-ASAs is that it releases earlier in your system based on pH levels.  I noticed a remarkable improvement within the first 24 hours (from pain and 8-10 loose BMs/day to pain-free and 3-4 formed BMs/day).  Since it was Memorial day weekend and pretty much stress-free, I thought some of the improvement might have been due to that and was waiting for symptoms to start up again on Tuesday once I got back to work.  I've now been through 3 extremely stressful work days and am still doing good.  Since the point of release seems to be the key here, I suspect that an individual's success with it would be dependent on where their crohn's is located.

 

heatmiser - There is a savings card for Apriso - if your doc doesn't have one you can sign up for it on the Apriso website (www.apriso-uc.com - click on the information and savings link in the upper left corner).  For some reason my savings card didn't work on the first shot (I activated it just a few minutes before picking up my script, so it may have been too soon), but between insurance and the savings card it should be free.

 

Bluize - It seems like there are different dosing options.  At first my doc said to try 2 in the am and 2 in the pm and if i was feeling better to switch to 4 in the am.  Then she changed her mind and said to start out taking all 4 in the am.  I didn't ask her why, but I'm guessing some of it is skepticism on the doc's part about having a constant stream of the meds in your system. (Lialda was suppossed to be once daily too, but my doc had me taking 2 in the am and 2 in the pm.)


33 - Diagnosed with Crohn's in Nov. '05
Current Meds: Apriso, Methotrexate, Pamine Forte, Aciphex, Domperidone, Folic Acid, VSL#3, lots of vitamins/supplements
Gluten free since Aug. '03


CrohnsPatient
Regular Member


Date Joined Feb 2008
Total Posts : 314
   Posted 5/28/2009 5:17 PM (GMT -7)   
Some of these are better for certain types of Crohns Disease then others, example being some of these release more in the colon, for people with crohns colitis, some release faster , in the small bowel, for general crohns disease or crohns in the terminal illieum

Bluize
Veteran Member


Date Joined Mar 2005
Total Posts : 635
   Posted 5/29/2009 8:32 AM (GMT -7)   

She told me to take 4 in the am and 4 in the pm.  I'm waiting for a call back.  I took 4 in the am yesterday with a new pro-bioitic and 4 again today and my intestines are not angry for the first time in years.

I have angry intestines.  I can't believe one or two doses could make a difference but if it's all about the release and the ph then I'm all for it.  Pentasa really never did the job.  I have moderate inflammation in the neo-ileum and patchy mild inflammation in the colon.  I also have some ulcers around those areas.  Finally I have mild inflammation and ulceration in my rectal/anal area but nothing major.  She said this med will work on those areas. 

I am also going to supplement with Canasa suppositories if I can bring myself to do that.

So instead of overdosing I'm just taking 4 in the am and waiting for her to give me clearer instructions.

 

 


Susan
 
28 years with Crohns in the term ileum.  Feb 07 Resection.  No meds currently..but there will be some I'm sure. Taking acidophilus.


mbw1103
Regular Member


Date Joined Apr 2009
Total Posts : 71
   Posted 5/29/2009 1:25 PM (GMT -7)   
Bluize - I'm glad it worked for you too.  My doctor didn't give me an indication of how long it would take...based on other 5-ASAs, I thought it would be at least a week or two before I felt any relief.  Like you, I was shocked at how quickly it calmed things down.  It sounds like you're making a good call with only taking 4 in the am, especially since it's working.  I re-read the dosing info last night and couldn't find anything about taking more than 4/day.
33 - Diagnosed with Crohn's in Nov. '05
Current Meds: Apriso, Methotrexate, Pamine Forte, Aciphex, Domperidone, Folic Acid, VSL#3, lots of vitamins/supplements
Gluten free since Aug. '03


Bluize
Veteran Member


Date Joined Mar 2005
Total Posts : 635
   Posted 5/29/2009 2:29 PM (GMT -7)   
that's why I'm not taking more.  I know what she said and I think she's very aggressive so it could be her way.  I'll do what she says because so far it's working.
 
She said within 2 weeks I should know if it's working.
 
I hope and pray that this is something I can stay on and will work and continue to be effective.
 
I never realized just how much pain I was in.  Because I can share here, I have to say I've only pooped once today!  That's down from 4-6 times. 
 
Ok, TMI..thanks for reading.
Susan
 
28 years with Crohns in the term ileum.  Feb 07 Resection.  No meds currently..but there will be some I'm sure. Taking acidophilus.

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