I have just been prescribed Apriso for Crohns. My doc tells me to take 4 in the am and 4 in the pm. Maybe it's different dosing for crohns vs UC also maybe it's in the beginning you take more and then go to a maintenance dose.
I'm bumping because I was searching and found this and it was exactly what my doc prescribed. This drug has been around for a while in Europe but it just got approved in the US.
I just switched from Lialda to Apriso on Saturday. Biopsies from a recent colonoscopy showed inflammation in my small bowel. I can't take steroids (bad reaction), so my doc suggested trying Apriso. I was skeptical since it's the same active ingredient as other 5-ASAs (mesalamine), but was willing to try anything. The big difference between Apriso and other 5-ASAs is that it releases earlier in your system based on pH levels. I noticed a remarkable improvement within the first 24 hours (from pain and 8-10 loose BMs/day to pain-free and 3-4 formed BMs/day). Since it was Memorial day weekend and pretty much stress-free, I thought some of the improvement might have been due to that and was waiting for symptoms to start up again on Tuesday once I got back to work. I've now been through 3 extremely stressful work days and am still doing good. Since the point of release seems to be the key here, I suspect that an individual's success with it would be dependent on where their crohn's is located.
heatmiser - There is a savings card for Apriso - if your doc doesn't have one you can sign up for it on the Apriso website (www.apriso-uc.com - click on the information and savings link in the upper left corner). For some reason my savings card didn't work on the first shot (I activated it just a few minutes before picking up my script, so it may have been too soon), but between insurance and the savings card it should be free.
Bluize - It seems like there are different dosing options. At first my doc said to try 2 in the am and 2 in the pm and if i was feeling better to switch to 4 in the am. Then she changed her mind and said to start out taking all 4 in the am. I didn't ask her why, but I'm guessing some of it is skepticism on the doc's part about having a constant stream of the meds in your system. (Lialda was suppossed to be once daily too, but my doc had me taking 2 in the am and 2 in the pm.)
She told me to take 4 in the am and 4 in the pm. I'm waiting for a call back. I took 4 in the am yesterday with a new pro-bioitic and 4 again today and my intestines are not angry for the first time in years.
I have angry intestines. I can't believe one or two doses could make a difference but if it's all about the release and the ph then I'm all for it. Pentasa really never did the job. I have moderate inflammation in the neo-ileum and patchy mild inflammation in the colon. I also have some ulcers around those areas. Finally I have mild inflammation and ulceration in my rectal/anal area but nothing major. She said this med will work on those areas.
I am also going to supplement with Canasa suppositories if I can bring myself to do that.
So instead of overdosing I'm just taking 4 in the am and waiting for her to give me clearer instructions.