Simponi - new RA drug, maybe soon crohn's drug too?

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PV
Veteran Member


Date Joined May 2006
Total Posts : 1163
   Posted 4/25/2009 12:29 AM (GMT -7)   
The makers of remicade, have released another anti-tnf drug, simponi:

www.nytimes.com/2009/04/25/business/25drug.html?ref=health

Someone posted earlier today or yesterday about an injectable remicade - perhaps this is what they were talking about. I know this is approved only for RA now, but perhaps soon it will be approved for crohn's as well. The more choices we have, the better right?
Husband with Crohn's
Diagnosed March 2003 Ulcerative Proctitis
Diagnosed March 2008 Crohn's & C-diff, hospitalized 45 days
Canasa, Lialda, Remicade, VSL#3, Florastor
In Remission since June 2008
Stopped vancomycin for c-diff Jan 1 2009
C-diff free, and in crohn's remission, knock on wood


ivy6
Elite Member


Date Joined Sep 2005
Total Posts : 10404
   Posted 4/25/2009 12:39 AM (GMT -7)   
Thanks for that, PV.

I just did a quick Google, and Simponi is actually Golimumab... which I *think* was in trial for UC but hasn't been tested in Crohn's yet? Is that right?

Ivy.
Co-Moderator Crohn's Forum.


onthecan
Regular Member


Date Joined Mar 2009
Total Posts : 317
   Posted 4/25/2009 9:47 AM (GMT -7)   
Choices are great when your running out of them i'm going to check it out or ask me GI when i go up next month thanks for the info. Jenn smilewinkgrin
Had Crohns 17 years had numerous bowel resections,fistulas,fissures,hemmies,kidney problems,fibro,arthritis,dignosed at 13 had GI feeding tube,nasal feeding tube,cental lines,ports,4 ruptured bowel emergency surgeries,TMJ,depression,current meds are Hydromorphone,30 ,Hydromophome,8 ,Ketoprofen,100 ,Trazadone,50 ,Lorazepam,10 ,Zopliclone,5 ,atriplyine,75 ,Losac,50 Tylenol Athritis ,B-12 injections ,Iron injections ,Gravol,75 Predisone,5mg ,Humira,40mg once a week.Still looking for the doctor with all the answers if you find him forward him to me please.P.S my bathroom is the nicest room in my house cause i spend so much time there,i am thinking about installing the computer and maybe a hot-dog stand.


sr5599
Veteran Member


Date Joined Aug 2007
Total Posts : 1202
   Posted 4/25/2009 11:53 AM (GMT -7)   
Thanks for the info! Any advances are good news... Hopefully it will make its way to the Crohn's world. We sure could use more chances.
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone
--Prochymal in Phase III study (can't wait til it's approved!)
--started Tysabri 3/21/08 => STOPPED 10/3/08 not enough response
--currently taking budesonide suppositories, 3mg at night.  Started Cimzia first dose 2/10/09.  Dx Osteoporosis 10/08 started Forteo 1/27/09
--single mom to 11-yr-old girl


Iram
Regular Member


Date Joined Jul 2003
Total Posts : 145
   Posted 4/25/2009 12:31 PM (GMT -7)   
here is more info:

http://news.prnewswire.com/ViewContent.aspx?ACCT=109&STORY=/www/story/04-24-2009/0005012746&EDATE=

This does not seem to have been tested for ibd patients, but seems to work the same way as humira/remcaide, etc

Lisa430
Regular Member


Date Joined May 2007
Total Posts : 112
   Posted 4/25/2009 8:02 PM (GMT -7)   
Does anyone know if the new drug has a mouse protein in it like the Remicade does?

Iram
Regular Member


Date Joined Jul 2003
Total Posts : 145
   Posted 4/27/2009 12:08 PM (GMT -7)   
I think it is based on human protein.

big mike nj
New Member


Date Joined Sep 2009
Total Posts : 1
   Posted 9/16/2009 5:40 PM (GMT -7)   
I was just prescribed simponi for my arthritis, but i have crohn's for 12 years aswell..
I had bad reactions to humira, cimzia and remicade..

Ill keep ya updated on the progress..

Rider Fan
Veteran Member


Date Joined May 2008
Total Posts : 1434
   Posted 9/16/2009 6:58 PM (GMT -7)   
Good luck Mike.
33 y/o male. Dx'ed in 1999. No surgeries.

Current meds: Humira 2/27/09. Proferrin iron pills.

Tried SCD, didn't work, now avoiding gluten and dairy.


Go Saskatchewan Roughriders!


Ides
Forum Moderator


Date Joined Nov 2003
Total Posts : 6841
   Posted 9/16/2009 9:57 PM (GMT -7)   
I've been taking Simponi since June. I just gave myself my fourth injection last week. It has worked very well at controlling the inflammation associatewd with my Ankylosing Spondylitis [AS]. AS was the reason Simponi was prescribed for me. As a side benefit, I have noticed that my CD gut issues are better since I began the injections. I took Remicade for 2.5 years before it lost its effectiveness. I took Humira for 2.5 months and then had a bad reaction. This is why I began Simponi.
Moderator Crohn's Disease  & Osteoarthritis Forums
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, asthma, severe allergy and a host of other medical problems.
 

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