I don't know if pred can make it happen, but even when not on pred I used to get it a lot when I was flaring for a long time, Nebraskagirl. I call it "puppet strings", because in posture I feel like a puppet with its strings cut ! At it's worst I cannot stand upright properly, always have to lean on things, practically can't walk, and even sitting upright is a real effort. The first warning sign is an inability to clench my fist, accompanied by a numbness that goes from the wrist up the inside of the forearm. The feeling is very similar to the onset of hypothermia.
In my case, chronic malnutrition is definitely the cause; which aspect of it, I am still not sure.
A high sugar, boom and bust energy cycle diet seems to make it more likely to happen, which used to make me think it was just blood sugar problems (if "just" is the word to use). But nowadays I wonder if it is not associated with adrenal gland fatigue, I gather there is a kind of burnout that can happen with these and certainly I have found that taking B5 to counteract this has been concurrent with an improvement in my overall fatigue levels.
In my case, as ever, I've never been offered anything by a mainstream medic that would help with this. Diet has been the deciding factor in avoiding this problem - lots of calories, mainly from organic vegetables and grains, with some fish protein to slow down carbohydrate loading, and paying lots of attention to nutrients like calcium, iron and most of all magnesium, which so many non-organic foods are now deficient in. I am now at the stage where I can't avoid being ill, but I can have stomach problems for weeks on end and no longer get the muscle weakness I used to.
Basically, I found it was one of the symptoms that always showed up when my Crohn's was at its worst, and as my "worst" has improved over time the symptom has become much more intermittent and less lengthy. Where years ago I used to countless days like that, I had it the other day for just a couple of hours, and that's the first time in a good long while.
So there is hope for you yet !