I assume they are STOPPING the Enbrel before starting the Humira. It is contraindicated to take two anti-TNFs at the same time.
Now to your question - it is/was thought that taking an immunosuppressing agent like MTX or Imuran while on an anti-TNF reduced the likelihood of having a reaction to the medication. There reason I said "is/was" is due to a change in thinking after some studies showed that there was an increased risk for lymphoma when taking Remicade and Imuran simultaneously. Physicians of some patients here that were on Remicade and/or Humira and Imuran stopped the Imuran because of this study. Other doctors feel that the risk is quite low and that patients need both. Imuran as is MTX is used as a "maintenance" medication to keep the autoimmune diseases at bay.
I took Remicade and then Humira while on Imuran. I ended up reacting to both TNF agents and just take Imuran now. My CD [guts] are in remission but I am still battling AS problems, primarily enthesitis. about
a year ago I was encouraged to switch to MTX but I refused. I enjoy occasionally having drinks with friends or when out for the evening. I was concerned about
the effects of alcohol on the liver that was dealing with MTX. Why is it you would prefer not to take it? Recently my rheumy added Plaquenil to my Imuran to battle my autoimmune issues. I do think it is helping.
And I forgot to welcome you to Healing Well - welcome!!
Moderator Crohn's Disease Forum
CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.