Recent study of Pentasa

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Writer
Regular Member


Date Joined Aug 2006
Total Posts : 443
   Posted 5/15/2009 5:55 PM (GMT -7)   
There's been some back and forth over the years about the value of the 5-ASA drugs in Crohn's. Here's the latest contribution to the debate (a recently published study of Pentasa), for those who might be interested.

FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4219
   Posted 5/15/2009 7:51 PM (GMT -7)   
Hey Writer,

I was only able to read the abstract. Were they studying the drug as a maintenence med or to get someone out of a flare and then keep remission? It seemed like as a maintenence med. I see a big difference in myself when I take my medication and when I don't. I know it works for me. Could you explain the study better to me. First they say you were twice as likely to remain in remission, but then the other group was the opposite? I'm confused. They conclude with it not being effective. I'm curious why it works so well for me...
27 Year old married female law student (last year!!). Diagnosed w/ CD 4 years ago, IBS for over 10 years before that, which was probably the CD. I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid. For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn. I also have bad acid reflux and have been on PPI's since age 13. I have been through prilosec, prevacid, and nexium. Currently I am on Protonix in the morning and Zantac at night.  I take xanax prn for situational anxiety (aka no easy bathroom access). 


spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 5/15/2009 10:06 PM (GMT -7)   
Maybe it works differently in children than adults? The study was done on pediatric patients.
34 years old, Crohn's disease for 15 of them
Current Meds: Humira since 7/08, Pentasa, Effexor XR
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, B-Complex, Vitamins D, E, & K, Calcium, Magnesium, Enzymes
SCD since 12/01/08 - eating Stage 3 foods


CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 5/15/2009 11:25 PM (GMT -7)   
There have been several studies now resulting in the theory that mesalamine is not particularly effective for maintenance of remission or in bringing about remission.

It does help to keep me in remission. But the studies seem to indicate otherwise. I can't help but wonder how much the conclusion of the studies are affected by the current infatuation w/the biologics and the money the research and clinical trials w/the biologics brings in.

Personally I think these clinical trials pitting new med against placebo are a CROCK. ESPECIALLY, when the CDAI is the "tool" used to determine remission or response. I'd have a heck of a lot more confidence in clinical trial results pitting new med against current med.


Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

Post Edited (CrohnieToo) : 5/16/2009 12:29:47 AM (GMT-6)


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 5/16/2009 8:21 AM (GMT -7)   
I am with Fitzy and C2 here. I take Asacol and it works amazingly well for me and it keeps me in remission too. I wouldn't be surprised to see that its doing it for others too. I also believe they try to say all this because of the big money research for the biologics etc as C2 said.

So far 3 for 3 who are maintained successfully solely by 5ASA's. JMHO
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

spookyh
Veteran Member


Date Joined Oct 2008
Total Posts : 1342
   Posted 5/16/2009 8:51 AM (GMT -7)   
I'm afraid I'm one who Pentasa/Asacol doesn't do much for. Humira has been the drug that really helped me. My colonoscopy last week showed a normal colon, with the exception of scarring. With Pentasa/Asacol, I never had a good colonoscopy (the last one showed severe perirectal disease). I wish I could do well on one of the 5ASA's, but as it is, I'm very happy that biologics are out there.
34 years old, Crohn's disease for 15 of them
Current Meds: Humira since 7/08, Pentasa, Effexor XR
Supplements: 3 kinds of Fish Oil, Multi-Vitamin, B-Complex, Vitamins D, E, & K, Calcium, Magnesium, Enzymes
SCD since 12/01/08 - eating Stage 3 foods


mel05
Regular Member


Date Joined Jan 2008
Total Posts : 87
   Posted 5/16/2009 9:15 AM (GMT -7)   
I didn't read the study, but wanted to say that I have stayed in complete remission using only pentasa for over a year now. :-)
Diagnosed with crohn's in January 2008! 
Pentasa 1000 mg 4 times a day
 
I am 28 years old and have been married for 3 years.  My husband and I are expecting our first child in November!


LMills
Veteran Member


Date Joined Apr 2008
Total Posts : 1753
   Posted 5/16/2009 10:18 AM (GMT -7)   
Pentasa keeps me well. It really has made such a big difference. And that is versus its sister asacol as well. I guess it just depends on the timing and dose, but it really has helped me.
20 years old, Diagnosed with moderate to severe Crohn's and Colitis in May of 2008.
Currently taking:
Prednisone 10 mg, pentasa 2 pills 4x a day, bentyl as needed, omeprazole in the morning, prenatal multivitamin, humira every other week, and Align probiotics given to me by my GI.
Surgery for ectopic pregnancy most likely the result of severe Crohn's inflammation in July of 2008.
Diet almost completely without refined sugars, wheat, flour, gluten, high lactose dairy, and/or junk food in general.
Learning how to live again.
"He who has a why to live for can bear with almost any how."


Zanne
Veteran Member


Date Joined Apr 2005
Total Posts : 3763
   Posted 5/16/2009 10:49 AM (GMT -7)   
Pentasa made my D worse. So I'm not one of the ones helped. I did take it for years, it may have kept the disease at bay, but the D was worse. I found out by "accident" when I was admitted to the hospital once a few years back and it wasn't ordered by the admitting doc. So by the time I was discharged and started to take it again, I couldn't believe how much worse my D became. A little trial and experimenting later, and I was making less bathroom runs off Pentasa than on. So with my doctors permission, I stopped taking it.
Suzanne

CD 20 years officially, 30 unofficially. 3 resections '93, '95 '97
Managing with strict low residue diet, keeping symptoms to a minimum. All test show small amount of ulceration, still have occasional blockages. But still have a great time with my 2 daughters and husband!


Prednisone, 6MP,Prevacid, B12 shots, Bentyl, Xifaxan.....


Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 5/17/2009 7:22 AM (GMT -7)   
Hey Zanne the Pentasa made my diarrhea worse too. But after my resections they put me on Asacol instead, and life has been fairly good since.
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

Writer
Regular Member


Date Joined Aug 2006
Total Posts : 443
   Posted 5/18/2009 8:35 AM (GMT -7)   
Fitzy and others,

Unfortunately I haven't seen the full study. The reference popped up when I was doing a search for something else and I posted it thinking it might be of interest. I'll add an update at a later date whenever I have had a chance to take a look (I don't have easy access to this particular journal). As near as I can judge from the abstract (with the reservation that abstracts can be very misleading), it seems as if they may have started a small study, seen a trend toward improvement associated with use of Pentasa, and decided to increase the size of the study by enrolling additional patients to see if the trend reached statistical significance. But with a larger study population, it appears that the trend turned out to be simply a chance finding (which can occur, particularly with small study populations), and Pentasa was not superior to the placebo.

As to why it seems to help some people with Crohn's, who knows. Perhaps it works better for people whose disease is more similar to ulcerative colitis, since that is the FDA-approved indication for the drug and presumably it was proven more effective than placebo for people with UC. Regarding the speculation raised in the thread that attacks on Pentasa have been spurred by desire to stimulate sales of the biologic drugs, I don't think that works out from a chronological standpoint. The debate about whether the 5-ASA drugs are useful for Crohn's, not just ulcerative colitis, has been going on for years, as has the research attempting to settle the matter one way or the other. Excluding the present study from 2009, I know of 11 placebo-controlled studies of Pentasa. All but one were published between 1992 and 1997 (most in the early 90s), with remaining study published in 2000. The first biologic drug for Crohn's, Remicade, wasn't approved until 1998. I apologize if I upset anyone by posting the abstract, I just find it interesting to keep an eye on new research about Crohn's.

Nanners
Elite Member


Date Joined Apr 2005
Total Posts : 14995
   Posted 5/18/2009 8:59 AM (GMT -7)   
Well I can say that my Crohns at least is not closely similar to UC. I have Crohns in the most common area, the TI. So the theory of it working for folks with Crohns more similar to UC doesn't fly for me. I just think they work well for some, and not for others. Just like all the other meds out there. JMHO
Gail*Nanners* Co-Moderator for Anxiety/Panic Forum
Been living with Crohn's Disease for 33 years. Currently on Asacol, Prilosec, Estrace, Prinivil, Diltiazem, Percoset prn for pain, Zofran, Phenergan, Probiotics, and Calcium and Xanax as needed. Resections in 2002 and 2005. Also diagnosed with Fibromyalgia and Osteoarthritis and Anxiety. Currently my Crohns is in remission.
*Every tomorrow has two handles.  We can take hold of it by the handle of anxiety, or by the handle of faith"*

CrohnieToo
Veteran Member


Date Joined May 2003
Total Posts : 9448
   Posted 5/19/2009 3:20 PM (GMT -7)   
Yep, I agree w/Nanners. Some of us respond better to some drugs than others and you never really know until you try them. Hail, I well remember when they didn't have much to offer but asulfidine, NASTY STUFF! For me. For some it helped some. I don't think it was ever a particularly great drug for treating Crohn's, more like all they had that seemed to do any good at all. For some.
Some people are like Slinkies... Not really good for anything, but they still bring a smile to your face when you push them down a flight of stairs.

New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, December 03, 2016 8:42 AM (GMT -7)
There are a total of 2,732,059 posts in 300,984 threads.
View Active Threads


Who's Online
This forum has 151152 registered members. Please welcome our newest member, JesperTrottier.
238 Guest(s), 12 Registered Member(s) are currently online.  Details
clo2014, shliv, ashlingd, Chellety, pmm73, peanut307, Traveler, eat2bwell, snowboat, bdavis, JamesE, trumpet123


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer