Remicade: when does it start to work?

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Regular Member

Date Joined Feb 2009
Total Posts : 39
   Posted 5/16/2009 11:14 PM (GMT -6)   
I just had my second infusion of remicade 2 days ago and I have felt some relief from the pain in my abdomen, but I'm still feeling bloated and having trouble passing gas, and I have bloody liquid stools a few times a day. Does it just take longer for some people to benefit from this drug? Many of the success stories I've read tell of instant relief, and I'm definitely not feeling that. Anyone else have experiences like this? Am I being impatient?
Diagnosed with Crohn's in 2008. Currently taking Entocort and Pentasa.

Veteran Member

Date Joined Aug 2007
Total Posts : 1202
   Posted 5/16/2009 11:19 PM (GMT -6)   
For me, back when Remicade put me into remission, I noticed effects after the second infusion. Real differences after the third. Remember that even if the meds help, it takes time to heal up the damage and feel better.

Also, each TNF that's helped me, I didn't notice a thing until the 4th day after. Then I could start to feel it kick in. That's after it had built up.

Good luck and hang in there! I'll keep good thoughts for it kicking in soon!
--40 year old female, dx as UC in '04 (1st symptoms in '03), switched to Crohn's in '05, 1 fistula, crohn's colitis, limited to large intestine  --rejected (reaction/didn't work): Asacol, AZA, 6-MP, MTX, Remicade, Humira, prednisone, Tysabri
--Prochymal in Phase III study (can't wait til it's approved!)
--currently taking methylprednisolone 40mg-taper.  Started Cimzia first dose 2/10/09.  Dx Osteoporosis 10/08 started Forteo 1/27/09
--single mom to 11-yr-old girl

Regular Member

Date Joined Dec 2007
Total Posts : 414
   Posted 5/17/2009 4:28 AM (GMT -6)   
In the past I had immediate relief pretty much, but last time I was ill and had to have it one dose got me feeling a LOT better but it took a second dose to really feel 'normal' again. But last time I was severely ill and in a really bad way, probably the illest I've been with my Crohn's since using remicade so think that maybe because of how bad it was I needed more than usual to get it to work.


Regular Member

Date Joined Jan 2009
Total Posts : 51
   Posted 5/18/2009 3:42 AM (GMT -6)   
I've just started Remicade too - I'm having my second infusion tomorrow. Still waiting to notice any difference, hope it works for me!
Diagnosed with Crohn's disease in Sept 05 aged 24

Resection in Nov 06

Currently taking Remicade, 125mg azathioprine, iron, multivitamin, probiotics and omega 3
Previously taken Prednisolone, Entocort, Flagyl, Cipro, Pentasa

Elite Member

Date Joined Sep 2005
Total Posts : 10404
   Posted 5/18/2009 3:47 AM (GMT -6)   
It took a few weeks for me, too. Please do be patient. I'm pretty sure you'll know if / when it is working.
Co-Moderator Crohn's Forum.

New meds thread

Regular Member

Date Joined Mar 2005
Total Posts : 357
   Posted 5/18/2009 6:17 AM (GMT -6)   
I have had 2 infusions so far... after the first one I noticed a difference, after the second one not so much, but I'm hoping the third will be my charm! After each infusion I feel bloated and gassy for a couple of days, and somewhat sick to my stomach, but it passes.
32 year old female... diagnosed with Crohn's at age 16, then with proctitis in 2005... right hemi-coloctomy April 2001 (removed 12 inches)... currently taking 100mg 6MP, Canasa, acidolpholus, Protonix, B12 injections once a month, 20mg Prednisone, Bentyl and Percoset as needed... just started Remicade

Regular Member

Date Joined Feb 2009
Total Posts : 39
   Posted 5/18/2009 9:42 AM (GMT -6)   
Good to hear from all of you, thanks. I feel a lot more confident about that 3rd infusion now :)
Diagnosed with Crohn's in 2008. Currently taking Entocort and Pentasa.

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