Exciting New Crohn's Research

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ryan_jordan
Regular Member


Date Joined Jan 2009
Total Posts : 45
   Posted 6/29/2009 5:28 PM (GMT -7)   
I wanted to share some really exciting news about research into the causes of Crohn's and UC. The Human Microbiome Project is a huge $140 million project intended to identify bacteria that lives within humans. The project began in 2007; this year they have started a number of studies that are focused on identifying what bacteria live in the intestinal tract that may related to IBD. Personally I think this is the best research currently underway for IBD patients as I believe it has the potential to unlock the mystery of IBD causes and provide a foundation for finding a cure. The IBD projects were just announced and are one year in length. They include:

Digestive tract: Crohn’s Disease
$1 million
The relationship between the inflammatory bowel disease, Crohn’s disease, the intestinal microbiome, and bacterial proteins will be explored in samples from pairs of twins with and without the disease.

Ellen Li, M.D., Ph.D., Washington University School of Medicine, Saint Louis
Digestive tract: Crohn’s Disease
$980,000
This study will analyze the intestinal microbiome and disease subjects’ genetic factors to uncover relationships with Crohn’s disease, an inflammatory bowel disease.

Gary D. Wu, M.D., University of Pennsylvania School of Medicine, Philadelphia
Digestive tract, Crohn’s Disease
$1.1 million
Crohn’s Disease, a form of inflammatory bowel disease, in children is typically treated with a liquid nutrient diet. It is not known how this treatment works. This team will investigate whether it works by altering the composition of the intestinal microbiome. Partial funding for this project will be provided by NIH’s Office of Dietary Supplements.

Vincent B. Young, M.D., Ph.D., University of Michigan, Ann Arbor
Digestive tract: Ulcerative Colitis
$1 million
Some patients who suffer from ulcerative colitis, a type of inflammatory bowel disease that causes inflammation and sores in the lining of the rectum and colon, are treated with surgical removal of the colon, followed by construction of a pouch to assist the patient with bowel movements. For unknown reasons, some, patients develop inflammation of the pouch, necessitating further surgery. This research will determine whether the composition of the pouch microbiome influences the onset and progression of pouch inflammation.

For more information about the recently announced studies:
www.nih.gov/news/health/jun2009/nhgri-23.htm

For more information about the Human Microbiome Project:
www.nihroadmap.nih.gov/hmp/

Post Edited (ryan_jordan) : 6/29/2009 6:44:43 PM (GMT-6)


janicea
Regular Member


Date Joined Feb 2009
Total Posts : 350
   Posted 6/29/2009 5:37 PM (GMT -7)   
thanks for posting this!
strictures, crohn's, adhesions, endo. Pyoderma Gangrenosum.
LDN 4mg ~ Boswellia Serrata ~ Olive Leaf extract ~ SCD yogurt. Using silver sulfadiazine on Pyoderma . B-12 shots. Juicing veggies!


ryan_jordan
Regular Member


Date Joined Jan 2009
Total Posts : 45
   Posted 6/29/2009 5:46 PM (GMT -7)   
janicea said...
thanks for posting this!


You're welcome!

Writer
Regular Member


Date Joined Aug 2006
Total Posts : 443
   Posted 6/29/2009 7:22 PM (GMT -7)   
I, too, find this very interesting. Thank you for posting it.

EMom
Veteran Member


Date Joined Aug 2007
Total Posts : 990
   Posted 6/29/2009 7:55 PM (GMT -7)   
VERY ENCOURAGING!!! yeah Thanks for posting that!

Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 6/29/2009 8:34 PM (GMT -7)   
Thanks for posting this.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications: Asacol, Precription Folic Acid, Multivitamin, 1000mg Calcium, Vitamin D, Probiotics,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.


J-
Regular Member


Date Joined Jun 2009
Total Posts : 86
   Posted 6/29/2009 9:25 PM (GMT -7)   
there is hope! very cool!!!!!!

thank you much
diagnosed with crohn's 6-15-09 at age 23.

meds:
asacol: 400mg. 3 3X a day
prednisone: 10mg. 3 in the morning

supplements:
multivitamin, cal/mag, probiotic, digestive enzymes, rice protein. looking into l-glutamine next


p47
New Member


Date Joined Jul 2009
Total Posts : 2
   Posted 7/7/2009 5:18 PM (GMT -7)   
Glad to hear people know about this!  I am actually working on my PhD and I am part of this project.  I have collected (and provided) some of the biopsies from which we are isolating the bacteria and along with the BROAD have begun sequencing hundreds of the bacteria we have found.  Unfortunately, we are a long way from finding all the causes and cures of IBD (there is not just one cause), but we are working on this one piece of the puzzle and I hope that oneday we can make a difference. 
 
Don't give up everyone.  I have days when I feel I can't go on, but my research helps me find a purpose in my suffering and gives me hope.

janicea
Regular Member


Date Joined Feb 2009
Total Posts : 350
   Posted 7/7/2009 7:12 PM (GMT -7)   
p47: how cool is THAT!! Not the crohn's part LOL -- your research part!! I hope you keep us posted and educated!
strictures, crohn's, adhesions, endo. Pyoderma Gangrenosum.
LDN 4mg ~ Boswellia Serrata ~ Olive Leaf extract ~ SCD yogurt. Using silver sulfadiazine on Pyoderma . B-12 shots. Juicing veggies!


Wolfie40
Veteran Member


Date Joined Dec 2008
Total Posts : 947
   Posted 7/8/2009 4:26 AM (GMT -7)   
Very encouraging.
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications: Asacol, Precription Folic Acid, Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Protonix,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.

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