Mastic for Crohn's diseaseChios mastic treatment of patients with active Crohn's disease.World J Gastroenterol. 2007 Feb 7;13(5):748-53. Kaliora AC, Stathopoulou MG, Triantafillidis JK, Dedoussis GV, Andrikopoulos NK. Department of Science of Dietetics-Nutrition, Harokopio University of Athens, 70 El. Venizelou ave., Kallithea 17671, Athens, Greece. To evaluate the effectiveness of mastic administration on the clinical course and plasma inflammatory mediators of patients with active Crohn's disease. This pilot study was conducted in patients with established mild to moderately active Crohn's disease, attending the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Activity Index (CDAI), Nutritional Risk Index (NRI), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Patients exhibited significant reduction of CDAI as compared to pretreament values. Plasma IL-6 was significantly decreased, and so did CRP. TAP was significantly increased. No patient or control exhibited any kind of side effects. The results suggest that mastic significantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately active Crohn's disease. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with Crohn's disease.
"Galland: At least 75% recover, become antigen- and antibody-negative and their symptoms clear up. I see only about a 10% relapse rate. But I’ve begun to be fascinated by other uses of mastic gum for gastrointestinal disorders. I had a patient with inflammatory bowel disease—with both gastritis and ulcerative colitis—who was H. pylori positive. I put her on mastic gum and her colitis cleared up. It was quite dramatic. She was on the mastic gum for six months total, and her symptoms have not returned. That was pretty amazing. I wasn’t sure if this was a fluke, but there have been recent studies with mastic gum that show it is quite helpful in a number of different gastrointestinal disorders. A 2007 study from the University of Athens showed that mastic actually altered the function of certain immune cells in patients with active Crohn’s disease. Another 2007 study showed that in patients with active Crohn’s disease, mastic gum downregulated inflammatory markers like NF-Kappa B and interleukin-6, as well as C-reactive protein. Their Crohn’s symptoms also improved. Research last year even showed that mastic gum can inhibit salivary bacteria."