c-diff, false negatives, and the wrong antibiotics?

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patientspiders
Veteran Member


Date Joined Jul 2005
Total Posts : 733
   Posted 7/10/2009 6:24 PM (GMT -7)   
I know there are many c-diff posts, but I didn't want to "hi-jack" someone else's post...

I have tested negatively for C-Diff twice in the last two weeks.

I was put on Xifaxan because my doc didn't know what else to do with me, and a burst of Prednisone starting at 20mg.

Since starting Xifaxan 38 hours ago:
my fevers are worse
my diarrhea is worse
my pain is worse
and to top it all off...

my bm's suddenly smell up the entire house (abnormal for me!)

AND the stupid little pamphlet that comes with the Xifaxan specifically says NOT to use if you suspect C-Diff. Well. I suspect C-Diff still, but my doc obviously doesn't.

Could the Xifaxan be making this worse? C-Diff experts, what would you do? I can demand a third test I guess?

My doc is useless at this point, and I'm waiting to go in for a second opinion, so I'm kind of past the whole "call your doctor" phase. He'll just ell me to go to the ER, again. You guys know the routine. Your 2 cents are much appreciated!
27f, dx'd CD July '05 after 6 fistula/abscess surgeries
Remicade '05 through '08, with no other maintenance meds (ah, those were the days, eh?)
Tried Humira. Failed. Tried Gluten Free. Leaning towards Failure there too.
Currently on:
Cimzia (started 2-12-09) Again, not helping much, if at all.
Probiotics, Digestive Enzymes, Forvia vitamins, and calcium chewies
Feeling a bit jaded lately, but trying to keep my chin up.


MAG102886
Veteran Member


Date Joined Jul 2008
Total Posts : 674
   Posted 7/10/2009 7:23 PM (GMT -7)   
C-diff tests show false negatives all the time. I was told by my doctor that standard procedure is 3 tests to be sure.  The first time I was diagnosed it took 3 tests, this last time took one....Id ask for another test especially if the meds say NOT to take it if its c-diff.
Dianogsed with Crohns: At 16 years old. 22 years old now.
Surgeries:2 Bowel Resections, Gallbladder Removed.
Current Meds: Imuran 50mg, Vitamin B12 (injection), D, and C tablets. Fish Oil Tablets, Cats Claw, Slippery Elm, and Reishi.
 

lenagirl
Regular Member


Date Joined Aug 2007
Total Posts : 44
   Posted 7/10/2009 10:59 PM (GMT -7)   
Yes, false negatives are totally par for the course. The test is so unreliable that they made me do 4 tests before that would release me from the hospital. My GI basically doesn't even bother testing me for the recurrances half the time now when I get sick because I can tell from my symptoms more reliably than from any test.
I don't know anthing about xifaxan, but certain anti-biotics do have the potential to make c.diff, so I would be wary of it, especially due to the note in the packet. And fever, pain, diarhhea, and abnormal BM smell would all be getting worse if it is c.diff.
What does your doctor think is going on that needs to be treated with xifixan? Since flagyl is used fairly frequently in Crohn's anyway AND can treat c. diff, can't you try a course of that?
If your condition continues to deteriorate, and your doctor is no help, I would recommend going to the ER. If you have c diff they'll put you on IV flagyl and vancomycin and it will wipe it out pretty quick.
21 years old, diagnosed with CD at age 18,
First major flare since diagnosis started in Nov. 08. Still recovering and mostly stable, but having trouble tapering Pred.

Current Meds:
Prednisone 12.5 mg, Azathioprine 100 mg (started 5/03/09, think it may be starting to kick in), Asacol, and Rowasa
Plus Vancomycin and Florastor for a recurring case of c diff.


D&G's Mommy
Regular Member


Date Joined Jan 2005
Total Posts : 185
   Posted 7/11/2009 2:35 AM (GMT -7)   
Just got out of the hospital myself and they wanted three tests on three separate days before taking my C-diff sign off the door. In the meantime, the infectious disease doc started Flagyl just in case. Turns out didn't have it. Just a horrendous reaction to the augmentin I had to take to clear the strep that created a giant outbreak of guttate psoriasis. Good Luck!
Cathy
Mommy to a 5 and 6-year-old
Currently on Humira, questran from time to time.
Using acupuncture.

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