Interesting article in Science Daily

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Date Joined Feb 2009
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   Posted 7/22/2009 10:37 AM (GMT -6)   
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Toward An Explanation For Crohn's Disease?

ScienceDaily (July 20, 2009) — Twenty-five per cent of Crohn's disease patients have a mutation in what is called the NOD2 gene, but it is not precisely known how this mutation influences the disease. The latest study by Dr. Marcel Behr, of the Research Institute of the MUHC and McGill University, has provided new insight into how this might occur.

When the NOD2 gene functions normally, it codes for a receptor that will recognize invading bacteria and then trigger the immune response. This study demonstrates that the NOD2 receptor preferentially recognizes a peptide called N-glycolyl-MDP, which is only found in a specific family of bacteria called mycobacteria. When mycobacteria invade the human body, they cause an immediate and very strong immune response via the NOD2 receptor.

"Now that we have a better understanding of the normal role of NOD2, we think that a mutation in this gene prevents mycobacteria from being properly recognized by the immune system," explained Dr. Behr. "If mycobacteria are not recognized, the body cannot effectively fight them off and then becomes persistently infected."

Researchers were already aware of the relationship between mycobacteria and Crohn's disease, but they did not know whether the presence of bacteria was a cause or a consequence of the disease. This new discovery associates the predisposition for Crohn's disease with both the NOD2 mutation and the presence of mycobacteria, but researchers must still determine the precise combination of these factors to understand how the disease develops.

More research is required to establish a complete explanation. From this, it is expected that new therapeutic approaches that fight the cause of Crohn's disease may be developed

This study was funded by a grant from the Canadian Institutes of Health Research (CIHR). The salaries of some researchers were provided by the Fonds de la recherche en santé du Québec.

The study will be published on July 9th in the Journal of Experimental Medicine. This article was co-authored by François Coulombe, Maziar Divanghi, Frédéric Veyrier, Louis de Léséleuc, Dr. Michael B. Reed and Dr Marcel Behr from the Research Institute of the MUHC; James L. Gleason of McGill University; and Yibin Yang, Michelle A. Kelliher, Amit K. Pandey, and Christopher M. Sassetti of the University of Massachusetts Medical School.
Adapted from materials provided by McGill University Health Centre.
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McGill University Health Centre (2009, July 20). Toward An Explanation For Crohn's Disease?. ScienceDaily. Retrieved July 22, 2009, from­ /releases/2009/07/090709095429.htm

strictures, crohn's, adhesions, endo. Pyoderma Gangrenosum.
LDN 4mg ~ Boswellia Serrata ~ Olive Leaf extract ~ SCD yogurt. Using silver sulfadiazine on Pyoderma . B-12 shots. Juicing veggies!

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Date Joined May 2007
Total Posts : 1488
   Posted 7/23/2009 10:40 PM (GMT -6)   
I saw that article and I'm glad someone posted it. Thanks from all of us!
Dx'd Jan'06, 1st Resection 7/06, Humira, Imuran, B12 injections, Nexium, Lexapro, Nulev, Glucosamine, Multi-Vitamin, Calcium Citrate, Ultracet. Secondary conditions: Psorasis, Osteoarthritis, Fibromyalgia, Lactose Intolerant, gallstones, kidney stones & peri-menopausal.

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Date Joined Jun 2008
Total Posts : 1058
   Posted 7/24/2009 12:19 AM (GMT -6)   
It would be more interesting to see a report that showed the mutated NOD2 did not respond to mycobacteria. So far it is "we think that a mutation in this gene prevents mycobacteria from being properly recognized by the immune system." That is not " mutated NOD2 does not recognize mycobacteria". It would not be that much more work to demonstrate that.

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Date Joined Dec 2008
Total Posts : 947
   Posted 7/24/2009 6:04 AM (GMT -6)   
Very interesting.
Thank you!
Diagnosed with Crohns in 2001
First and hopefully last Ileocecectomy 2/18/2009

Medications: Asacol, Precription Folic Acid, Multivitamin, 1000mg Calcium, Vitamin D, Probiotics, Protonix,  Monthly B-12 injections.

Living a Great life with my Wife and my two Chocolate Labs
Hunter & Hailey.
I love them dearly.

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Date Joined May 2007
Total Posts : 1220
   Posted 7/24/2009 7:09 AM (GMT -6)   
I think I am "persistently infected"
Diagnosed with Crohn's in early 2007.  Several peri-rectal abscesses and two fistulae with setons.  Allergic to Remicade and Humira.  Currently on 6MP, and vitamins D and B-12.

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